Status: Bibliographieeintrag
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| Verfasst von: | Nunes, Daniel [VerfasserIn]  |
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| | Kuner, Thomas [VerfasserIn] |
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| Titel: | Axonal sodium channel NaV1.2 drives granule cell dendritic GABA release and rapid odor discrimination |
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| Verf.angabe: | Daniel Nunes, Thomas Kuner |
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| E-Jahr: | 2018 |
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| Jahr: | August 20, 2018 |
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| Umfang: | 27 S. |
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| Fussnoten: | Im Titel ist V in NaV1.2 tiefgestellt ; Gesehen am 04.03.2020 |
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| Titel Quelle: | Enthalten in: Public Library of SciencePLoS biology |
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| Ort Quelle: | Lawrence, KS : PLoS, 2003 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 16 (2018,8) Artikel-Nummer e2003816, Seite 1-27, 27 Seiten |
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| ISSN Quelle: | 1545-7885 |
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| Abstract: | Dendrodendritic synaptic interactions between olfactory bulb mitral and granule cells represent a key neuronal mechanism of odor discrimination. Dendritic release of gamma-aminobutyric acid (GABA) from granule cells contributes to stimulus-dependent, rapid, and accurate odor discrimination, yet the physiological mechanisms governing this release and its behavioral relevance are unknown. Here, we show that granule cells express the voltage-gated sodium channel α-subunit NaV1.2 in clusters distributed throughout the cell surface including dendritic spines. Deletion of NaV1.2 in granule cells abolished spiking and GABA release as well as inhibition of synaptically connected mitral cells (MCs). As a consequence, mice required more time to discriminate highly similar odorant mixtures, while odor discrimination learning remained unaffected. In conclusion, we show that expression of NaV1.2 in granule cells is crucial for physiological dendritic GABA release and rapid discrimination of similar odorants with high accuracy. Hence, our data indicate that neurotransmitter-releasing dendritic spines function just like axon terminals |
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| DOI: | doi:10.1371/journal.pbio.2003816 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1371/journal.pbio.2003816 |
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| | Volltext: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003816 |
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| | DOI: https://doi.org/10.1371/journal.pbio.2003816 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Action potentials |
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| | Cognition |
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| | Gamma-aminobutyric acid |
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| | Granule cells |
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| | Green fluorescent protein |
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| | Hyperpolarization |
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| | Immunohistochemistry techniques |
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| | Neuronal dendrites |
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| K10plus-PPN: | 169157452X |
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| Verknüpfungen: | → Zeitschrift |
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Axonal sodium channel NaV1.2 drives granule cell dendritic GABA release and rapid odor discrimination / Nunes, Daniel [VerfasserIn]; August 20, 2018 (Online-Ressource)
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