Prolonged antibiotic prophylaxis after thoracoabdominal esophagectomy does not reduce the risk of pneumonia in the first 30 days

• Verfasst von: Hochreiter, Marcel [VerfasserIn]
• Verfasst von: Uhling, Maria [VerfasserIn]
• Verfasst von: Peters, Leila [VerfasserIn]
• Verfasst von: Bruckner, Thomas [VerfasserIn]
• Verfasst von: Heininger, Alexandra [VerfasserIn]
• Verfasst von: Schmidt, Thomas [VerfasserIn]
• Verfasst von: Berger, Marc Moritz [VerfasserIn]
• Verfasst von: Richter, Daniel [VerfasserIn]
• Verfasst von: Büchler, Markus W. [VerfasserIn]
• Verfasst von: Weigand, Markus A. [VerfasserIn]
• Verfasst von: Busch, Cornelius [VerfasserIn]
• Titel: Prolonged antibiotic prophylaxis after thoracoabdominal esophagectomy does not reduce the risk of pneumonia in the first 30 days
• Titelzusatz: a retrospective before-and-after analysis
• Verf.angabe: Marcel Hochreiter, Maria Uhling, Leila Sisic, Thomas Bruckner, Alexandra Heininger, Andreas Hohn, Katja Ott, Thomas Schmidt, Marc Moritz Berger, Daniel Christoph Richter, Markus Büchler, Markus Alexander Weigand, Cornelius Johannes Busch
• E-Jahr: 2018
• Jahr: 05 June 2018
• Umfang: 8 S.
• Fussnoten: Gesehen am 06.03.2020
• Titel Quelle: Enthalten in: Infection
• Ort Quelle: München : Urban & Vogel, 1973
• Jahr Quelle: 2018
• Band/Heft Quelle: 46(2018), 5, Seite 617-624
• ISSN Quelle: 1439-0973
• DOI: doi:10.1007/s15010-018-1160-2
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1691815519

Abstract

Purpose: Thoracoabdominal esophageal resection for malignant disease is frequently associated with pulmonary infection. Whether prolonged antibiotic prophylaxis beyond a single perioperative dose is advantageous in preventing pulmonary infection after thoracoabdominal esophagectomy remains unclear. Methods: In this retrospective before-and-after analysis, 173 patients between January 2009 and December 2014 from a prospectively maintained database were included. We evaluated the effect of a 5-day postoperative course of moxifloxacin, which is a frequently used antimicrobial agent for pneumonia, on the incidence of pulmonary infection and mortality after thoracoabdominal esophagectomy. Results: 104 patients received only perioperative antimicrobial prophylaxis (control group) and 69 additionally received a 5-day postoperative antibiotic therapy with moxifloxacin (prolonged-course). 22 (12.7%) of all patients developed pneumonia within the first 30 days after surgery. No statistically significant differences were seen between the prolonged group and control group in terms of pneumonia after 7 (p = 0.169) or 30 days (p = 0.133), detected bacterial species (all p > 0.291) and 30-day mortality (5.8 vs 10.6%, p = 0.274). Conclusion: A preemptive 5-day postoperative course of moxifloxacin does not reduce the incidence of pulmonary infection and does not improve mortality after thoracoabdominal esophagectomy.