Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Freire Valls, Aida [VerfasserIn]   i
 Knipper, Karl [VerfasserIn]   i
 Giannakouri, Evangelia [VerfasserIn]   i
 Sarachaga, Víctor [VerfasserIn]   i
 Hinterkopf, Sascha [VerfasserIn]   i
 Wührl, Michael [VerfasserIn]   i
 Shen, Ying [VerfasserIn]   i
 Radhakrishnan, Praveen [VerfasserIn]   i
 Klose, Johannes [VerfasserIn]   i
 Ulrich, Alexis [VerfasserIn]   i
 Schneider, Martin [VerfasserIn]   i
 Augustin, Hellmut [VerfasserIn]   i
 Ruiz de Almodóvar, Carmen [VerfasserIn]   i
 Schmidt, Thomas [VerfasserIn]   i
Titel:VEGFR1+ metastasis-associated macrophages contribute to metastatic angiogenesis and influence colorectal cancer patient outcome
Verf.angabe:Aida Freire Valls, Karl Knipper, Evangelia Giannakouri, Víctor Sarachaga, Sascha Hinterkopf, Michael Wuehrl, Ying Shen, Praveenkumar Radhakrishnan, Johannes Klose, Alexis Ulrich, Martin Schneider, Hellmut G. Augustin, Carmen Ruiz de Almodovar, and Thomas Schmidt
E-Jahr:2019
Jahr:June 25, 2019
Umfang:12 S.
Fussnoten:Gesehen am 05.03.2020 ; Das Zeichen "+" ist im Titel hochgestellt
Titel Quelle:Enthalten in: Clinical cancer research
Ort Quelle:Philadelphia, Pa. [u.a.] : AACR, 1995
Jahr Quelle:2019
Band/Heft Quelle:25(2019), 18, Seite 5674-5685
ISSN Quelle:1557-3265
Abstract:PURPOSE: To investigate the clinical relevance of macrophages in liver metastasis of colorectal cancer and their influence on angiogenesis and patient survival. Moreover to evaluate specific blood monocytes as markers of disease recurrence.Experimental design: In a mouse model with spontaneous liver metastasis, the angiogenic characteristics of tumor- and metastasis (MAM)-associated macrophages were evaluated. Macrophages and the vasculature from 130 primary tumor (pTU) and 123 patients with liver metastasis were assessed. In vivo and in human samples, the clinical relevance of macrophage VEGFR1 expression was analyzed. Blood samples from patients (n = 157, 80 pTU and 77 liver metastasis) were analyzed for assessing VEGFR1-positive (VEGFR1+) cells as suitable biomarkers of disease recurrence. - RESULTS: The number of macrophages positively correlated with vascularization in metastasis. Both in the murine model as well as in primary isolated human cells, a subpopulation of MAMs expressing VEGFR1 were found highly angiogenic. While VEGFR1 expression in pTU patients did not predict prognosis; high percentage of VEGFR1+ cells in liver metastasis was associated with worse patient outcome. Interestingly, VEGFR1+-circulating monocytes in blood samples from patients with liver metastasis not only predicted progression but also site of recurrence. - CONCLUSIONS: Our findings identify a new subset of proangiogenic VEGFR1+ MAMs in colorectal cancer that support metastatic growth and may become a liquid biomarker to predict disease recurrence in the liver.
DOI:doi:10.1158/1078-0432.CCR-18-2123
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1158/1078-0432.CCR-18-2123
 DOI: https://doi.org/10.1158/1078-0432.CCR-18-2123
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1691766674
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68497965   QR-Code
zum Seitenanfang