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Verfasst von:Shmarlouski, Anatoli [VerfasserIn]   i
 Hesser, Jürgen [VerfasserIn]   i
 Stsepankou, Dzmitry [VerfasserIn]   i
Titel:A novel analysis technique for transcutaneous measurement of glomerular filtration rate with ultralow dose marker concentrations
Verf.angabe:Anatoli Shmarlouski, Daniel Schock-Kusch, Yury Shulhevich, Volker Buschmann, Tino Röhlicke, Deborah Herdt, Matthias Rädle, Jürgen Hesser, Dzmitry Stsepankou
E-Jahr:2016
Jahr:Aug. 2016
Umfang:9 S.
Fussnoten:Gesehen am 05.03.2020
Titel Quelle:Enthalten in: Institute of Electrical and Electronics EngineersIEEE transactions on biomedical engineering
Ort Quelle:New York, NY : IEEE, 1964
Jahr Quelle:2016
Band/Heft Quelle:63(2016), 8, Seite 1742-1750
ISSN Quelle:1558-2531
Abstract:Objective: A novel high-precision approach [lifetime-decomposition measurement (LTDM)] for the assessment of the glomerular filtration rate (GFR) based on clearance measurements of exogenous filtration marker. Methods: The time-correlated single photon counting (TCSPC) acquisition in combination with a new decomposition method allows the separation of signal and background from transcutaneous measurements of GFR. Results: The performance of LTDM is compared versus the commercially available NIC-kidney patch-based system for transcutaneous GFR measurement. Measurements are performed in awake Sprague Dawley (SD) rats. Using the standard concentration required for the NIC-kidney system [7-mg/100-g body weight (b.w.) FITC-Sinistrin] as reference, the mean difference (bias) of the elimination curves GFR between LTDM and NIC-kidney was 4.8%. On the same animal and same day, the capability of LTDM to measure GFR with a FITC-Sinistrin dose reduced by a factor of 200 (35-μg/100-g b.w.) was tested as well. The mean differences (half lives with low dose using LTDM compared with those using first, the NIC-Kidney system and its standard concentration, and second, LTDM with the same concentration as for the NIC-Kidney system) were 3.4% and 4.5%, respectively. Conclusion: We demonstrate that with the LTDM strategy substantial reductions in marker concentrations are possible at the same level of accuracy. Significance: LTDM aims to resolve the issue of the currently necessary large doses of fluorescence tracer required for transcutaneous GFR measurement. Due to substantially less influences from autofluorescence and artifacts, the proposed method outperforms other existing techniques for accurate percutaneous organ function measurement.
DOI:doi:10.1109/TBME.2015.2501544
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

DOI: https://doi.org/10.1109/TBME.2015.2501544
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Algorithms
 Animals
 biological fluid dynamics
 Biomarkers
 Biomedical measurement
 clearance measurement
 elimination curves
 exogenous filtration marker
 Fluoresceins
 Fluorescence
 Fluorescent Dyes
 glomerular filtration rate
 Glomerular Filtration Rate
 Glomerular filtration rate (GFR)
 Histograms
 kidney
 Kidney
 kidney function
 Kidney Function Tests
 lifetime decomposition measurement
 Male
 NIC-kidney patch based system
 Oligosaccharides
 Optical fibers
 patient diagnosis
 Photonics
 Rats
 Rats, Sprague-Dawley
 Reproducibility of Results
 Sensitivity and Specificity
 signal-background separation
 skin
 Skin
 Sprague Dawley rats
 time correlated single photon counting
 time-correlated single photon counting (TCSPC)
 transcutaneous
 transcutaneous measurement
 ultralow dose marker concentration
K10plus-PPN:1691771686
Verknüpfungen:→ Zeitschrift

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