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Verfasst von:Bazarbachi, Ali [VerfasserIn]   i
 Dreger, Peter [VerfasserIn]   i
Titel:Brentuximab vedotin prior to allogeneic stem cell transplantation in Hodgkin lymphoma
Titelzusatz:a report from the EBMT Lymphoma Working Party
Verf.angabe:Ali Bazarbachi, Ariane Boumendil, Hervé Finel, Mohamad Mohty, Luca Castagna, Karl S. Peggs, Didier Blaise, Boris Afanasyev, José L. Diez‐Martin, Jorge Sierra, Adrian Bloor, Carmen Martinez, Stephen Robinson, Ram Malladi, Jean El‐Cheikh, Paolo Corradini, Silvia Montoto, Peter Dreger and Anna Sureda
E-Jahr:2018
Jahr:22 February 2018
Umfang:11 S.
Fussnoten:Gesehen am 09.03.2020
Titel Quelle:Enthalten in: British journal of haematology
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1955
Jahr Quelle:2018
Band/Heft Quelle:181(2018), 1, Seite 86-96
ISSN Quelle:1365-2141
Abstract:Brentuximab vedotin (BV) is an anti-CD30 antibody-drug conjugate. Preliminary data suggest that BV might improve outcomes after allogeneic stem cell transplantation (SCT) for Hodgkin lymphoma (HL) when used as pre-transplant salvage therapy. Between 2010 and 2014, 428 adult patients underwent an allogeneic SCT for classical HL at participating centres of the European Society for Blood and Marrow Transplantation. We compared the outcomes of 210 patients who received BV prior to allogeneic SCT with that of 218 patients who did not receive BV. The median follow-up for survivors was 41 months. Patients in the BV group were more heavily pre-treated (median pre-allograft treatment lines: 4 vs. 3). The two groups were comparable in terms of disease status, performance status, comorbidities, prior autologous SCT, type of donor, conditioning and in vivo T cell depletion. In multivariate analysis, pre-allograft BV had no impact on acute graft-versus-host disease (GVHD), non-relapse mortality, cumulative incidence of relapse, progression-free survival or overall survival (OS), but significantly reduced the risk of chronic GVHD (hazard ratio = 0·64; 95% confidence interval = 0·45-0·92; P < 0·02). Older age, poor performance status, use of pre-transplant radiotherapy and active disease at SCT adversely affected OS. Patients allografted for HL after prior exposure to BV do not have a superior outcome after allogeneic SCT except for a lower risk of chronic GVHD. However, BV may improve the outlook of allogeneic SCT by helping otherwise refractory patients to achieve a more favourable disease status, facilitating allotransplant success.
DOI:doi:10.1111/bjh.15152
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1111/bjh.15152
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bjh.15152
 DOI: https://doi.org/10.1111/bjh.15152
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:allogeneic stem cell transplant
 Hodgkin lymphoma
 salvage therapy
 stem cell transplantation
K10plus-PPN:1691878561
Verknüpfungen:→ Zeitschrift

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