Physiological and unappreciated roles of CaMKII in the heart

• Verfasst von: Beckendorf, Jan [VerfasserIn]
• Verfasst von: Hoogenhof, Maarten van den [VerfasserIn]
• Verfasst von: Backs, Johannes [VerfasserIn]
• Titel: Physiological and unappreciated roles of CaMKII in the heart
• Verf.angabe: Jan Beckendorf, Maarten M.G. van den Hoogenhof, Johannes Backs
• E-Jahr: 2018
• Jahr: 15 June 2018
• Umfang: 12 S.
• Fussnoten: Gesehen am 09.03.2020
• Titel Quelle: Enthalten in: Basic research in cardiology
• Ort Quelle: [Darmstadt u.a.] : Steinkopff, 1937
• Jahr Quelle: 2018
• Band/Heft Quelle: 113(2018,4) Artikel-Nummer 29, 12 Seiten
• ISSN Quelle: 1435-1803
• DOI: doi:10.1007/s00395-018-0688-8
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1691913820

Abstract

In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation-contraction and also excitation-transcription coupling. Its activity can be regulated in response to changes in intracellular calcium content as well as after several post-translational modifications. Some of the effects mediated by CaMKII may be considered adaptive, while effects of sustained CaMKII activity may turn into the opposite and are detrimental to cardiac integrity and function. As such, CaMKII has long been noted as a promising target for pharmacological inhibition, but the ubiquitous nature of CaMKII has made it difficult to target CaMKII specifically where it is detrimental. In this review, we provide a brief overview of the physiological and pathophysiological properties of CaMKII signaling, but we focus on the physiological and adaptive functions of CaMKII. Furthermore, special consideration is given to the emerging role of CaMKII as a mediator of inflammatory processes in the heart.