A red-shifted two-photon-only caging group for three-dimensional photorelease

• Verfasst von: Bartel, Yvonne [VerfasserIn]
• Verfasst von: Dreuw, Andreas [VerfasserIn]
• Titel: A red-shifted two-photon-only caging group for three-dimensional photorelease
• Verf.angabe: Yvonne Becker, Erik Unger, Manuela A.H. Fichte, Daniel A. Gacek, Andreas Dreuw, Josef Wachtveitl, Peter J. Walla and Alexander Heckel
• E-Jahr: 2018
• Jahr: 09 Feb 2018
• Umfang: 6 S.
• Fussnoten: Gesehen am 10.03.2020
• Titel Quelle: Enthalten in: Chemical science
• Ort Quelle: Cambridge : RSC, 2010
• Jahr Quelle: 2018
• Band/Heft Quelle: 9(2018), 10, Seite 2797-2802
• ISSN Quelle: 2041-6539
• DOI: doi:10.1039/C7SC05182D
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1691966908

Abstract

Based on nitrodibenzofuran (NDBF) a new photocage with higher two-photon action cross section and red-shifted absorption was developed. Due to calculations, a dimethylamino functionality (DMA) was added at ring position 7. The uncaging of nucleobases after two-photon excitation (2PE) could be visualized via double-strand displacement in a hydrogel. With this assay we achieved three-dimensional photorelease of DMA-NDBF-protected DNA orthogonal to NDBF-protected strands. While being an excellent 2P-cage, DMA-NDBF is surprisingly stable under visible-light one-photon excitation (1PE). This case of excitation-specific photochemistry enhances the scope of orthogonal photoregulation.