7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions

• Verfasst von: Behrens, Janina R. [VerfasserIn]
• Verfasst von: Jarius, Sven [VerfasserIn]
• Verfasst von: Wildemann, Brigitte [VerfasserIn]
• Titel: 7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions
• Werktitel: Seven Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions
• Verf.angabe: Janina R. Behrens, Julia Wanner, Joseph Kuchling, Lennard Ostendorf, Lutz Harms, Klemens Ruprecht, Thoralf Niendorf, Sven Jarius, Brigitte Wildemann, René M. Gieß, Michael Scheel, Judith Bellmann‐Strobl, Jens Wuerfel, Friedemann Paul & Tim Sinnecker
• E-Jahr: 2018
• Jahr: 29 June 2018
• Umfang: 13 S.
• Fussnoten: Gesehen am 10.03.2020
• Titel Quelle: Enthalten in: Annals of Clinical and Translational Neurology
• Ort Quelle: Chichester [u.a.] : Wiley, 2013
• Jahr Quelle: 2018
• Band/Heft Quelle: 5(2018), 8, Seite 900-912
• ISSN Quelle: 2328-9503
• DOI: doi:10.1002/acn3.572
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1692000756

Abstract

Background: Baló's concentric sclerosis (BCS) is a rare condition characterized by concentrically layered white matter lesions. While its pathogenesis is unknown, hypoxia-induced tissue injury and chemotactic stimuli have been proposed as potential causes of BCS lesion formation. BCS has been suggested to be a variant of multiple sclerosis (MS). Here, we aimed to elucidate similarities and differences between BCS and MS by describing lesion morphology and localization in high-resolution 7 Tesla (7 T) magnetic resonance imaging (MRI) scans. Methods: Ten patients with Baló-type lesions underwent 7 T MRI, and 10 relapsing remitting MS patients served as controls. The 7 T MR imaging protocol included 3D T1-weighted (T1w) magnetization-prepared rapid gradient echo, 2D high spatial resolution T2*-weighted (T2*w) fast low-angle shot and susceptibility-weighted imaging. Results: Intralesional veins were visible in the center of all but one Baló-type lesion. Four Baló-type lesions displayed inhomogeneous intralesional T2*w signal intensities, which are suggestive of microhemorrhages or small ectatic venules. Eight of 10 BCS patients presented with 97 additional lesions, 36 of which (37%) had a central vein. Lesions involving the cortical gray matter and the U-fibers were not detected in BCS patients. Conclusion: Our findings support the hypothesis that BCS and MS share common pathogenetic mechanisms but patients present with different lesion phenotypes.