Dynamics of particle uptake at cell membranes

• Verfasst von: Frey, Felix [VerfasserIn]
• Verfasst von: Ziebert, Falko [VerfasserIn]
• Verfasst von: Schwarz, Ulrich S. [VerfasserIn]
• Titel: Dynamics of particle uptake at cell membranes
• Verf.angabe: Felix Frey, Falko Ziebert, and Ulrich S. Schwarz
• E-Jahr: 2019
• Jahr: 14 November 2019
• Umfang: 18 S.
• Fussnoten: Gesehen am 11.03.2020
• Titel Quelle: Enthalten in: Physical review
• Ort Quelle: Woodbury, NY : Inst., 2016
• Jahr Quelle: 2019
• Band/Heft Quelle: 100(2019,5) Artikel-Nummer 052403, 18 Seiten
• ISSN Quelle: 2470-0053
• DOI: doi:10.1103/PhysRevE.100.052403
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1692283707

Abstract

Receptor-mediated endocytosis requires that the energy of adhesion overcomes the deformation energy of the plasma membrane. The resulting driving force is balanced by dissipative forces, leading to deterministic dynamical equations. While the shape of the free membrane does not play an important role for tensed and loose membranes, in the intermediate regime it leads to an important energy barrier. Here we show that this barrier is similar to but different from an effective line tension and suggest a simple analytical approximation for it. We then explore the rich dynamics of uptake for particles of different shapes and present the corresponding dynamical state diagrams. We also extend our model to include stochastic fluctuations, which facilitate uptake and lead to corresponding changes in the phase diagrams.