| |  Online-Ressource |
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| Verfasst von: | Trautmann, Marcel [VerfasserIn]  |
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| | Cheng, Ya-Yun [VerfasserIn] |
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| | Jensen, Patrizia [VerfasserIn] |
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| | Hüllein, Jennifer [VerfasserIn] |
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| | Słabicki, Mikołaj [VerfasserIn] |
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| | Zenz, Thorsten [VerfasserIn] |
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| | Scholl, Claudia [VerfasserIn] |
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| | Fröhling, Stefan [VerfasserIn] |
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| Titel: | Requirement for YAP1 signaling in myxoid liposarcoma |
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| Verf.angabe: | Marcel Trautmann, Ya-Yun Cheng, Patrizia Jensen, Ninel Azoitei, Ines Brunner, Jennifer Hüllein, Mikolaj Slabicki, Ilka Isfort, Magdalene Cyra, Ruth Berthold, Eva Wardelmann, Sebastian Huss, Bianca Altvater, Claudia Rossig, Susanne Hafner, Thomas Simmet, Anders Ståhlberg, Pierre Åman, Thorsten Zenz, Undine Lange, Thomas Kindler, Claudia Scholl, Wolfgang Hartmann & Stefan Fröhling |
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| E-Jahr: | 2019 |
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| Jahr: | 21 March 2019 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 25.06.2020 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationEMBO molecular medicine |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2009 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 11(2019,5) Artikel-Nummer e9889, 15 Seiten |
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| ISSN Quelle: | 1757-4684 |
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| Abstract: | Abstract Myxoid liposarcomas (MLS), malignant tumors of adipocyte origin, are driven by the FUS-DDIT3 fusion gene encoding an aberrant transcription factor. The mechanisms whereby FUS-DDIT3 mediates sarcomagenesis are incompletely understood, and strategies to selectively target MLS cells remain elusive. Here we show, using an unbiased functional genomic approach, that FUS-DDIT3-expressing mesenchymal stem cells and MLS cell lines are dependent on YAP1, a transcriptional co-activator and central effector of the Hippo pathway involved in tissue growth and tumorigenesis, and that increased YAP1 activity is a hallmark of human MLS. Mechanistically, FUS-DDIT3 promotes YAP1 expression, nuclear localization, and transcriptional activity and physically associates with YAP1 in the nucleus of MLS cells. Pharmacologic inhibition of YAP1 activity impairs the growth of MLS cells in vitro and in vivo. These findings identify overactive YAP1 signaling as unifying feature of MLS development that could represent a novel target for therapeutic intervention. |
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| DOI: | doi:10.15252/emmm.201809889 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.15252/emmm.201809889 |
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| | Volltext: https://www.embopress.org/doi/full/10.15252/emmm.201809889 |
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| | DOI: https://doi.org/10.15252/emmm.201809889 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | FUS-DDIT3 |
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| | Hippo pathway |
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| | myxoid liposarcoma |
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| | verteporfin |
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| | YAP1 |
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| K10plus-PPN: | 1692364421 |
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| Verknüpfungen: | → Zeitschrift |
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Requirement for YAP1 signaling in myxoid liposarcoma / Trautmann, Marcel [VerfasserIn]; 21 March 2019 (Online-Ressource)
