Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Hanisch, Stephanie [VerfasserIn]  |
| Stachel, Nicole [VerfasserIn]  |
| Skopp, Gisela [VerfasserIn]  |
Titel: | A potential new metabolite of gamma-hydroxybutyrate |
Titelzusatz: | sulfonated gamma-hydroxybutyric acid |
Verf.angabe: | Stephanie Hanisch, Nicole Stachel, Gisela Skopp |
Jahr: | 2016 |
Jahr des Originals: | 2015 |
Umfang: | 4 S. |
Fussnoten: | Published online: 26 July 2015 ; Gesehen am 12.03.2020 |
Titel Quelle: | Enthalten in: International journal of legal medicine |
Ort Quelle: | Berlin : Springer, 1922 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 130(2016), 2, Seite 411-414 |
ISSN Quelle: | 1437-1596 |
Abstract: | Detection of gamma-hydroxybutyric acid (GHB) became crucial in many clinical and forensic settings due to its increasing use for recreational purposes and drug-facilitated sexual assault. Its narrow window of detection of about 3-12 h in urine represents a major problem. Analogous to ethyl glucuronide, the recently identified GHB-glucuronide exhibits a longer window of detection than the parent drug. It appeared reasonable that a sulfonated metabolite of GHB (GHB-SUL) will also be formed. Due to the lack of an appropriate standard, GHB was incubated with a human liver cytosolic fraction to produce GHB-SUL. Following development of a liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay to measure GHB and GHB-SUL, authentic urine samples (n = 5) were tested for GHB-SUL. These investigations revealed detectable signals of both GHB and GHB-SUL, strongly indicating that GHB is not only glucuronidated but also sulfonated. Given that sulfonated metabolites generally have longer half-life times than the corresponding free drugs, GHB-SUL may serve as a biomarker of GHB misuse along with its glucuronide. |
DOI: | doi:10.1007/s00414-015-1235-x |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00414-015-1235-x |
| Volltext: https://link.springer.com/article/10.1007%2Fs00414-015-1235-x |
| DOI: https://doi.org/10.1007/s00414-015-1235-x |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 169238872X |
Verknüpfungen: | → Zeitschrift |
¬A¬ potential new metabolite of gamma-hydroxybutyrate / Hanisch, Stephanie [VerfasserIn]; 2016 (Online-Ressource)
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