Imaging biomarkers of behavioral impairments

• Verfasst von: Dijk, Roelof Maarten van [VerfasserIn]
• Verfasst von: Liberto, Valentina Di [VerfasserIn]
• Verfasst von: Brendel, Matthias [VerfasserIn]
• Verfasst von: Waldron, Ann Marie [VerfasserIn]
• Verfasst von: Möller, Christina [VerfasserIn]
• Verfasst von: Gildehaus, Franz Josef [VerfasserIn]
• Verfasst von: Ungern-Sternberg, Barbara von [VerfasserIn]
• Verfasst von: Lindner, Magdalena [VerfasserIn]
• Verfasst von: Ziegler, Sibylle [VerfasserIn]
• Verfasst von: Hellweg, Rainer [VerfasserIn]
• Verfasst von: Gass, Peter [VerfasserIn]
• Verfasst von: Bartenstein, Peter [VerfasserIn]
• Verfasst von: Potschka, Heidrun [VerfasserIn]
• Titel: Imaging biomarkers of behavioral impairments
• Titelzusatz: a pilot micro-positron emission tomographic study in a rat electrical post-status epilepticus model
• Verf.angabe: R. Maarten van Dijk, Valentina Di Liberto, Matthias Brendel, Ann Marie Waldron, Christina Möller, Franz Josef Gildehaus, Barbara von Ungern-Sternberg, Magdalena Lindner, Sibylle Ziegler, Rainer Hellweg, Peter Gass, Peter Bartenstein, Heidrun Potschka
• E-Jahr: 2018
• Jahr: 28 October 2018
• Umfang: 12 S.
• Fussnoten: Gesehen am 13.03.2020
• Titel Quelle: Enthalten in: Epilepsia
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1909
• Jahr Quelle: 2018
• Band/Heft Quelle: 59(2018), 12, Seite 2194-2205
• ISSN Quelle: 1528-1167
• DOI: doi:10.1111/epi.14586
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 18FFDG
• Sach-SW: 18FMPPF
• Sach-SW: animal model
• Sach-SW: epilepsy
• Sach-SW: psychiatric comorbidities
• K10plus-PPN: 1692482564

Abstract

Objective In patients with epilepsy, psychiatric comorbidities can significantly affect the disease course and quality of life. Detecting and recognizing these comorbidities is central in determining an optimal treatment plan. One promising tool in detecting biomarkers for psychiatric comorbidities in epilepsy is positron emission tomography (PET). Methods Behavioral and biochemical variables were cross-correlated with the results from two μPET scans using the tracers [18F]fluoro-2-deoxy-D-glucose ([18F]FDG) and 2′-methoxyphenyl-(N-2′-pyridinyl)-p-18F-fluoro-benzamidoethylpiperazine ([18F]MPPF) to explore potential biomarkers for neurobehavioral comorbidities in an electrically induced post-status epilepticus rat model of epilepsy. Results In rats with epilepsy, μPET analysis revealed a local reduction in hippocampal [18F]FDG uptake, and a local increase in [18F]MPPF binding. These changes exhibited a correlation with burrowing as a “luxury” behavior, social interaction, and anxiety-associated behavioral patterns. Interestingly, hippocampal [18F]FDG uptake did not correlate with spontaneous recurrent seizure activity. Significance In the electrically induced post-status epilepticus rat model, we demonstrated hippocampal hypometabolism and its correlation with a range of neurobehavioral alterations. These findings require further confirmation in other preclinical models and patients with epilepsy and psychiatric disorders to address the value of [18F]FDG uptake as an imaging biomarker candidate for psychiatric comorbidities in patients as well as for severity assessment in rodent epilepsy models.