Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Digomann, David [VerfasserIn]   i
 Linge, Annett [VerfasserIn]   i
 Dubrovska, Anna [VerfasserIn]   i
Titel:SLC3A2/CD98hc, autophagy and tumor radioresistance
Titelzusatz:a link confirmed
Verf.angabe:David Digomann, Annett Linge, Anna Dubrovska
E-Jahr:2019
Jahr:15 July 2019
Umfang:2 S.
Fussnoten:Gesehen am 19.03.2020
Titel Quelle:Enthalten in: Autophagy
Ort Quelle:Abingdon, Oxon : Taylor & Francis, 2005
Jahr Quelle:2019
Band/Heft Quelle:15(2019), 10, Seite 1850-1851
ISSN Quelle:1554-8635
Abstract:SLC3A2/CD98hc (solute carrier family 3 member 2) and its light chain subunits constitute the heterodimeric transmembrane complexes that mediate amino acid transport and regulate MTOR and macroautophagy/autophagy. Despite the proven tumorigenic role of SLC3A2 in a number of cancers including head and neck squamous cell carcinomas (HNSCC), the link between SLC3A2, autophagy regulation and tumor radioresistance remained elusive. In a recently published study we demonstrated that low levels of SLC3A2 and SLC7A5/LAT1 protein expression significantly correlate with good clinical prognosis in locally advanced HNSCC treated with primary radiochemotherapy. The SLC3A2-deficient HNSCC cells show a higher radiosensitivity and increased autophagy levels. We found that autophagy activation is a tumor survival strategy to overcome nutrient stress by lack of SLC3A2 and to withstand radiation-mediated cell damage. Inhibition of the autophagy activation in SLC3A2 knockout HNSCC cells by knockdown of ATG5 expression or treatment with bafilomycin A1 results in radiosensitivity. Consequently, the expression levels of ATG5 correlates with overall survival in HNSCC patients, and autophagy inhibition in combination with SLC3A2-targeted therapy can be a promising strategy for HNSCC radiosensitization.Abbreviations: CD98hc: CD98 heavy chain CSC cancer stem cells; EAA: essential amino acids; GSH: glutathione; MTOR: mammalian target of rapamycin; HNSCC: head and neck squamous cell carcinoma; RCTx: primary radiochemotherapy; PORT-C: postoperative radiochemotherapy; ROS: reactive oxygen species; SLC3A2: solute carrier family 3 member 2; TCA cycle: tricarboxylic acid cycle.
DOI:doi:10.1080/15548627.2019.1639302
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1080/15548627.2019.1639302
 DOI: https://doi.org/10.1080/15548627.2019.1639302
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Amino acid transporters
 ATG5
 autophagy
 biomarkers
 CD98hc
 HNSCC
 LAT1
 MTOR
 radiotherapy
 xCT
K10plus-PPN:1692987003
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68544046   QR-Code
zum Seitenanfang