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Status: Bibliographieeintrag

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Verfasst von:Zeiler, Frederick A. [VerfasserIn]   i
 Ercole, Ari [VerfasserIn]   i
 Cabeleira, Manuel [VerfasserIn]   i
 Carbonara, Marco [VerfasserIn]   i
 Stocchetti, Nino [VerfasserIn]   i
 Menon, David K. [VerfasserIn]   i
 Smielewski, Peter [VerfasserIn]   i
 Czosnyka, Marek [VerfasserIn]   i
 Sakowitz, Oliver [VerfasserIn]   i
 Younsi, Alexander [VerfasserIn]   i
Titel:Comparison of performance of different optimal cerebral perfusion pressure parameters for outcome prediction in adult traumatic brain injury
Titelzusatz:a collaborative European neurotrauma effectiveness research in traumatic brain injury (CENTER-TBI) study
Körperschaft:CENTER-TBI [VerfasserIn]   i
Verf.angabe:Frederick A. Zeiler, Ari Ercole, Manuel Cabeleira, Marco Carbonara, Nino Stocchetti, David K. Menon, Peter Smielewski, and Marek Czosnyka and the CENTER-TBI High Resolution (HR ICU) Sub-Study Participants and Investigators: Audny Anke, Ronny Beer, Bo-Michael Bellander, Andras Buki, Giorgio Chevallard, Giuseppe Citerio, Endre Czeiter, Bart Depreitere, Shirin Frisvold, Raimund Helbok, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Geert Meyfroidt, Kirsten Moeller, David Nelson, Anna Piippo-Karjalainen, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Saulius Rocka, Rolf Rossaint, Juan Sahuquillo, Oliver Sakowitz, Ana Stevanovic, Nina Sundström, Riikka Takala, Tomas Tamosuitis, Olli Tenovuo, Peter Vajkoczy, Alessia Vargiolu, Rimantas Vilcinis, Stefan Wolf, Alexander Younsi
E-Jahr:2019
Jahr:6 May 2019
Umfang:13 S.
Fussnoten:Gesehen am 23.03.2020
Titel Quelle:Enthalten in: Journal of neurotrauma
Ort Quelle:Larchmont, NY : Liebert, 1988
Jahr Quelle:2019
Band/Heft Quelle:36(2019), 10, Seite 1505-1517
ISSN Quelle:1557-9042
Abstract:It has been postulated previously that individualized cerebral perfusion pressure (CPP) targets can be derived from cerebrovascular reactivity indices. Differences between real CPP and target CPP (named generically optimal CPP) has been linked to global outcome in adult traumatic brain injury (TBI). Different vascular reactivity indices can be utilized in the determination. The goal of this study is to evaluate CPPopt parameters, derived from three intracranial pressure (ICP)-derived cerebrovascular reactivity indices, and determine which one is superior for 6- to 12-month outcome prediction. Using the prospectively collected data from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study, the following indices of cerebrovascular reactivity were derived: pressure reactivity index (PRx; correlation between ICP and mean arterial pressure [MAP]), pulse amplitude index (PAx; correlation between pulse amplitude of ICP [AMP] and MAP), and RAC (correlation between AMP and CPP). CPPopt was derived using each index. Univariate logistic regression models were created to assess the association between CPPopt with global dichotomized outcome at 6 to 12 months, as assessed by Glasgow Outcome Score-Extended. Models were compared via area under the receiver operating curve (AUC) and Delong's Test. A total of 204 patients had available data. CPPopt derived from PRx, PAx, and RAC performed variably in their association with outcomes. PRx- and RAC-based CPPopt performed similarly, with RAC parameters trending towards highest AUC values. PAx-based CPPopt parameters failed to reach significant associations with dichotomized outcomes at 6 to 12 months. CPPopt parameters derived from PRx and RAC appear similar in their overall ability for 6- to 12-month outcome prediction in moderate/severe adult TBI.
DOI:doi:10.1089/neu.2018.6182
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1089/neu.2018.6182
 DOI: https://doi.org/10.1089/neu.2018.6182
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:autoregulation
 CPP optimum
 ICP indices
 outcome analysis
K10plus-PPN:1693118319
Verknüpfungen:→ Zeitschrift

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