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Status: Bibliographieeintrag

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Verfasst von:Mayr, Roman [VerfasserIn]   i
 Gierth, Michael [VerfasserIn]   i
 Zeman, Florian [VerfasserIn]   i
 Reiffen, Marieke [VerfasserIn]   i
 Seeger, Philipp [VerfasserIn]   i
 Wezel, Felix [VerfasserIn]   i
 Pycha, Armin [VerfasserIn]   i
 Comploj, Evi [VerfasserIn]   i
 Bonatti, Matteo [VerfasserIn]   i
 Ritter, Manuel [VerfasserIn]   i
 van Rhijn, Bas W. G. [VerfasserIn]   i
 Burger, Maximilian [VerfasserIn]   i
 Bolenz, Christian [VerfasserIn]   i
 Fritsche, Hans-Martin [VerfasserIn]   i
 Martini, Thomas [VerfasserIn]   i
Titel:Sarcopenia as a comorbidity-independent predictor of survival following radical cystectomy for bladder cancer
Verf.angabe:Roman Mayr, Michael Gierth, Florian Zeman, Marieke Reiffen, Philipp Seeger, Felix Wezel, Armin Pycha, Evi Comploj, Matteo Bonatti, Manuel Ritter, Bas W.G. van Rhijn, Maximilian Burger, Christian Bolenz, Hans-Martin Fritsche & Thomas Martini
E-Jahr:2018
Jahr:25 February 2018
Umfang:9 S.
Fussnoten:Gesehen am 24.03.2020
Titel Quelle:Enthalten in: Journal of cachexia, sarcopenia and muscle
Ort Quelle:Hoboken, NJ : Wiley, 2010
Jahr Quelle:2018
Band/Heft Quelle:9(2018), 3, Seite 505-513
ISSN Quelle:2190-6009
Abstract:BACKGROUND: A multicentre study was conducted to investigate the impact of sarcopenia as an independent predictor of oncological outcome after radical cystectomy for bladder cancer. - METHODS: In total, 500 patients with available digital computed tomography scans of the abdomen obtained within 90 days before surgery were identified. The lumbar skeletal muscle index was measured using pre-operative computed tomography. Cancer-specific survival (CSS) and overall survival (OS) were estimated using Kaplan-Meier curves. Predictors of CSS and OS were analysed by univariable and multivariable Cox regression models. - RESULTS: Based on skeletal muscle index, 189 patients (37.8%) were classified as sarcopenic. Patients with sarcopenia were older compared with their counterparts (P = 0.002), but both groups were comparable regarding to gender, comorbidity, tumor, node, metastasis (TNM) stage, and type of urinary diversion (all P > 0.05). In total, 234 (46.8%) patients died, and of these, 145 (29.0%) died because of urothelial carcinoma of the bladder. Sarcopenic patients had significantly worse 5 year OS (38.3% vs. 50.5%; P = 0.002) and 5 year CSS (49.5% vs. 62.3%; P = 0.016) rates compared with patients without sarcopenia. Moreover, sarcopenia was associated independently with both increased all-cause mortality (hazard ratio, 1.43; 95% confidence interval 1.09-1.87; P = 0.01) and increased cancer-specific mortality (hazard ratio, 1.42; 95% confidence interval, 1.00-2.02; P = 0.048). Our results are limited by the lack of prospective frailty assessment. - CONCLUSIONS: Sarcopenia has been shown to be an independent predictor for OS and CSS in a large multicentre study with patients undergoing radical cystectomy for bladder cancer.
DOI:doi:10.1002/jcsm.12279
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/jcsm.12279
 DOI: https://doi.org/10.1002/jcsm.12279
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Aged
 Aged, 80 and over
 Biomarkers
 Bladder cancer
 Body Composition
 Comorbidity
 Cystectomy
 Female
 Frailty
 Humans
 Kaplan-Meier Estimate
 Male
 Muscle, Skeletal
 Postoperative Period
 Prognosis
 Proportional Hazards Models
 Sarcopenia
 Skeletal muscle mass
 Tomography, X-Ray Computed
 Urinary bladder neoplasm
 Urinary Bladder Neoplasms
K10plus-PPN:1693175800
Verknüpfungen:→ Zeitschrift

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