| Online-Ressource |
Verfasst von: | Oldenburg, Catherine [VerfasserIn]  |
| Bor, Jacob [VerfasserIn]  |
| Harling, Guy [VerfasserIn]  |
| Tanser, Frank [VerfasserIn]  |
| Mutevedzi, Tinofa [VerfasserIn]  |
| Shahmanesh, Maryam [VerfasserIn]  |
| Seage, George R. [VerfasserIn]  |
| De Gruttola, Victor [VerfasserIn]  |
| Mimiaga, Matthew J. [VerfasserIn]  |
| Mayer, Kenneth H. [VerfasserIn]  |
| Pillay, Deenan [VerfasserIn]  |
| Bärnighausen, Till [VerfasserIn]  |
Titel: | Impact of early antiretroviral therapy eligibility on HIV acquisition |
Titelzusatz: | household-level evidence from rural South Africa |
Verf.angabe: | Catherine E. Oldenburg, Jacob Bor, Guy Harling, Frank Tanser, Tinofa Mutevedzi, Maryam Shahmanesh, George R. Seage, Victor De Gruttola, Matthew J. Mimiaga, Kenneth H. Mayer, Deenan Pillay and Till Bärnighausen |
E-Jahr: | 2018 |
Jahr: | [March 13, 2018] |
Umfang: | 9 S. |
Illustrationen: | Diagramme |
Fussnoten: | Gesehen am 24.03.2020 |
Titel Quelle: | Enthalten in: AIDS <London> |
Ort Quelle: | London [u.a.] : Lippincott Williams & Wilkins, 1987 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 32(2018), 5, Seite 635-643 |
ISSN Quelle: | 1473-5571 |
Abstract: | Objectives: We investigate the effect of immediate antiretroviral therapy (ART) eligibility on HIV incidence among HIV-uninfected household members. - Design: Regression discontinuity study arising from a population-based cohort. - Methods: Household members of patients seeking care at the Hlabisa HIV Treatment and Care Programme in rural KwaZulu-Natal South Africa between January 2007 and August 2011 with CD4+ cell counts up to 350 cells/μl were eligible for inclusion if they had at least two HIV tests and were HIV-uninfected at the time the index patient linked to care (N = 4115). Regression discontinuity was used to assess the intention-to-treat effect of immediate versus delayed ART eligibility on HIV incidence among household members. Exploiting the CD4+ cell count-based threshold rule for ART initiation (CD4+ < 200 cells/μl until August 2011), we used Cox proportional hazards models to compare outcomes for household members of patients who presented for care with CD4+ cell counts just above versus just below the ART initiation threshold. - Results: Characteristics of household members of index patients initiating HIV care were balanced between those with an index patient immediately eligible for ART (N = 2489) versus delayed for ART (N = 1626). There were 337 incident HIV infections among household members, corresponding to an HIV incidence of 2.4 infections per 100 person-years (95% confidence interval 2.5-3.1). Immediate eligibility for treatment reduced HIV incidence in households by 47% in our optimal estimate (hazard ratio = 0.53, 95% confidence interval 0.30-0.96), and by 32-60% in alternate specifications of the model. - Conclusion: Immediate eligibility of ART led to substantial reductions in household-level HIV incidence. |
DOI: | doi:10.1097/QAD.0000000000001737 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1097/QAD.0000000000001737 |
| Volltext: https://journals.lww.com/aidsonline/FullText/2018/03130/Impact_of_early_antiretroviral_therapy_eligibility.12.aspx |
| DOI: https://doi.org/10.1097/QAD.0000000000001737 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1693193558 |
Verknüpfungen: | → Zeitschrift |
Impact of early antiretroviral therapy eligibility on HIV acquisition / Oldenburg, Catherine [VerfasserIn]; [March 13, 2018] (Online-Ressource)