TUSC3

• Verfasst von: Vašíčková, Kateřina [VerfasserIn]
• Verfasst von: Horak, Peter [VerfasserIn]
• Verfasst von: Vaňhara, Petr [VerfasserIn]
• Titel: TUSC3
• Titelzusatz: functional duality of a cancer gene
• Verf.angabe: Kateřina Vašíčková, Peter Horak, Petr Vaňhara
• E-Jahr: 2018
• Jahr: 19 September 2017
• Umfang: 9 S.
• Fussnoten: Gesehen am 25.03.2020
• Titel Quelle: Enthalten in: Cellular and molecular life sciences
• Ort Quelle: Cham (ZG) : Springer International Publishing AG, 1997
• Jahr Quelle: 2018
• Band/Heft Quelle: 75(2018), 5, Seite 849-857
• ISSN Quelle: 1420-9071
• DOI: doi:10.1007/s00018-017-2660-4
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1693277468

Abstract

Two decades ago, following a systematic screening of LOH regions on chromosome 8p22, TUSC3 has been identified as a candidate tumor suppressor gene in ovarian, prostate and pancreatic cancers. Since then, a growing body of evidence documented its clinical importance in various other types of cancers, and first initial insights into its molecular function and phenotypic effects have been gained, though the precise role of TUSC3 in different cancers remains unclear. As a part of the oligosaccharyltransferase complex, TUSC3 localizes to the endoplasmic reticulum and functions in final steps of N-glycosylation of proteins, while its loss evokes the unfolded protein response. We are still trying to figure out how this mechanistic function is reconcilable with its varied effects on cancer promotion. In this review, we focus on cancer-related effects of TUSC3 and envisage a possible role of TUSC3 beyond endoplasmic reticulum.