Meta-analysis of the prognostic role of perioperative platelet count in posthepatectomy liver failure and mortality

• Verfasst von: Mehrabi, Arianeb [VerfasserIn]
• Verfasst von: Golriz, Mohammad [VerfasserIn]
• Verfasst von: Khajeh, Elias [VerfasserIn]
• Verfasst von: Ghamarnejad, Omid [VerfasserIn]
• Verfasst von: Probst, Pascal [VerfasserIn]
• Verfasst von: Fonouni, Hamidreza [VerfasserIn]
• Verfasst von: Mohammadi, Sara [VerfasserIn]
• Verfasst von: Weiss, Karl Heinz [VerfasserIn]
• Verfasst von: Büchler, Markus W. [VerfasserIn]
• Titel: Meta-analysis of the prognostic role of perioperative platelet count in posthepatectomy liver failure and mortality
• Verf.angabe: A. Mehrabi, M. Golriz, E. Khajeh, O. Ghamarnejad, P. Probst, H. Fonouni, S. Mohammadi, K.H. Weiss, M.W. Büchler
• E-Jahr: 2018
• Jahr: 12 July 2018
• Umfang: 8 S.
• Fussnoten: Gesehen am 25.03.2020
• Titel Quelle: Enthalten in: The British journal of surgery
• Ort Quelle: Oxford : Oxford University Press, 1913
• Jahr Quelle: 2018
• Band/Heft Quelle: 105(2018), 10, Seite 1254-1261
• ISSN Quelle: 1365-2168
• DOI: doi:10.1002/bjs.10906
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Hepatectomy
• Sach-SW: Humans
• Sach-SW: Liver Failure
• Sach-SW: Models, Statistical
• Sach-SW: Odds Ratio
• Sach-SW: Perioperative Period
• Sach-SW: Platelet Count
• Sach-SW: Postoperative Complications
• Sach-SW: Prognosis
• Sach-SW: Risk Factors
• K10plus-PPN: 1693283395

Abstract

BACKGROUND: Emerging evidence suggests that the perioperative platelet count (PLT) can predict posthepatectomy liver failure (PHLF). In this systematic review and meta-analysis, the impact of perioperative PLT on PHLF and mortality was evaluated. - METHODS: MEDLINE and Web of Science databases were searched systematically for relevant literature up to January 2018. All studies comparing PHLF or mortality in patients with a low versus high perioperative PLT were included. Study quality was assessed using methodological index for non-randomized studies (MINORS) criteria. Meta-analyses were performed using Mantel-Haenszel tests with a random-effects model, and presented as odds ratios (ORs) with 95 per cent confidence intervals. - RESULTS: Thirteen studies containing 5260 patients were included in the meta-analysis. Two different cut-off values for PLT were used: 150 and 100/nl. Patients with a perioperative PLT below 150/nl had higher PHLF (4 studies, 817 patients; OR 4·79, 95 per cent c.i. 2·89 to 7·94) and mortality (4 studies, 3307 patients; OR 3·78, 1·48 to 9·62) rates than patients with a perioperative PLT of 150/nl or more. Similarly, patients with a PLT below 100/nl had a significantly higher risk of PHLF (4 studies, 949 patients; OR 4·65, 2·60 to 8·31) and higher mortality rates (7 studies, 3487 patients; OR 6·35, 2·99 to 13·47) than patients with a PLT of 100/nl or greater. - CONCLUSION: A low perioperative PLT correlates with higher PHLF and mortality rates after hepatectomy.