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| Verfasst von: | Schmid, Sabrina Franziska [VerfasserIn]  |
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| | Goldberg-Bockhorn, Eva [VerfasserIn] |
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| | Schwarz, Silke [VerfasserIn] |
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| | Rotter, Nicole [VerfasserIn] |
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| | Kassubek, Jan Rainer [VerfasserIn] |
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| | Del Tredici, Kelly [VerfasserIn] |
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| | Pinkhardt, Elmar Hans [VerfasserIn] |
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| | Otto, Markus [VerfasserIn] |
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| | Ludolph, Albert C. [VerfasserIn] |
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| | Oeckl, Patrick [VerfasserIn] |
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| Titel: | Alpha-synuclein is present in dental calculus but not altered in Parkinson's disease patients in comparison to controls |
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| Verf.angabe: | Sabrina Schmid, Eva Goldberg-Bockhorn, Silke Schwarz, Nicole Rotter, Jan Kassubek, Kelly Del Tredici, Elmar Pinkhardt, Markus Otto, Albert C. Ludolph, Patrick Oeckl |
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| E-Jahr: | 2018 |
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| Jahr: | 29 March 2018 |
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| Umfang: | 5 S. |
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| Fussnoten: | Published: 29 March 2018 ; Gesehen am 26.03.2020 |
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| Titel Quelle: | Enthalten in: Journal of neurology |
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| Ort Quelle: | [Darmstadt] : Steinkopff, 1891 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 265(2018), 6, Seite 1334-1337 |
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| ISSN Quelle: | 1432-1459 |
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| Abstract: | INTRODUCTION: In autopsy cases staged for sporadic Parkinson's disease (PD), the neuropathology is characterized by a preclinical phase that targets the enteric nervous system of the gastrointestinal tract (GIT). Therefore, the ENS might be a source of potential (presymptomatic) PD biomarkers. - METHODS: In this clinically based study, we examined the alpha-synuclein (αSyn) concentration in an easily accessible protein storage medium of the GIT, dental calculus, in 21/50 patients with PD and 28/50 age- and gender-matched controls using ELISA. - RESULTS: αSyn was detectable in dental calculus and the median concentration in the control patients was 8.6 pg/mg calculus (interquartile range 2.6-13.1 pg/mg). αSyn concentrations were significantly influenced by blood contamination and samples with a hemoglobin concentration of > 4000 ng/mL were excluded. There was no significant difference of αSyn concentrations in the dental calculus of PD patients (5.76 pg/mg, interquartile range 2.91-9.74 pg/mg) compared to those in controls (p = 0.40). - CONCLUSION: The total αSyn concentration in dental calculus is not a suitable biomarker for sporadic PD. Disease-related variants such as oligomeric or phosphorylated αSyn in calculus might prove to be more specific. |
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| DOI: | doi:10.1007/s00415-018-8847-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
DOI: https://doi.org/10.1007/s00415-018-8847-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Aged |
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| | alpha-Synuclein |
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| | Alpha-synuclein |
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| | Biomarker |
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| | Biomarkers |
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| | Dental calculus |
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| | Dental Calculus |
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| | Enzyme-Linked Immunosorbent Assay |
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| | Female |
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| | Humans |
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| | Male |
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| | Middle Aged |
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| | Parkinson Disease |
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| | Parkinson’s disease |
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| | Saliva |
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| K10plus-PPN: | 1693373254 |
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| Verknüpfungen: | → Zeitschrift |
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Alpha-synuclein is present in dental calculus but not altered in Parkinson's disease patients in comparison to controls / Schmid, Sabrina Franziska [VerfasserIn]; 29 March 2018 (Online-Ressource)
