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| Verfasst von: | Menden, Michael [VerfasserIn]  |
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| | Casale, Francesco Paolo [VerfasserIn] |
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| | Stephan, Johannes [VerfasserIn] |
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| | Bignell, Graham R. [VerfasserIn] |
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| | Iorio, Francesco [VerfasserIn] |
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| | McDermott, Ultan [VerfasserIn] |
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| | Garnett, Mathew J. [VerfasserIn] |
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| | Sáez Rodríguez, Julio [VerfasserIn] |
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| | Stegle, Oliver [VerfasserIn] |
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| Titel: | The germline genetic component of drug sensitivity in cancer cell lines |
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| Verf.angabe: | Michael P. Menden, Francesco Paolo Casale, Johannes Stephan, Graham R. Bignell, Francesco Iorio, Ultan McDermott, Mathew J. Garnett, Julio Saez-Rodriguez & Oliver Stegle |
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| E-Jahr: | 2018 |
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| Jahr: | 23 August 2018 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 30.03.2020 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 9(2018) Artikel-Nummer 3385, 8 Seiten |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Patients with seemingly the same tumour can respond very differently to treatment. There are strong, well-established effects of somatic mutations on drug efficacy, but there is at-most anecdotal evidence of a germline component to drug response. Here, we report a systematic survey of how inherited germline variants affect drug susceptibility in cancer cell lines. We develop a joint analysis approach that leverages both germline and somatic variants, before applying it to screening data from 993 cell lines and 265 drugs. Surprisingly, we find that the germline contribution to variation in drug susceptibility can be as large or larger than effects due to somatic mutations. Several of the associations identified have a direct relationship to the drug target. Finally, using 17-AAG response as an example, we show how germline effects in combination with transcriptomic data can be leveraged for improved patient stratification and to identify new markers for drug sensitivity. |
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| DOI: | doi:10.1038/s41467-018-05811-3 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-018-05811-3 |
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| | DOI: https://doi.org/10.1038/s41467-018-05811-3 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Benzoquinones |
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| | Cell Line, Tumor |
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| | Drug Screening Assays, Antitumor |
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| | Germ Cells |
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| | Germ-Line Mutation |
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| | Humans |
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| | Lactams, Macrocyclic |
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| | Neoplasms |
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| | Quantitative Trait Loci |
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| K10plus-PPN: | 1693488450 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ germline genetic component of drug sensitivity in cancer cell lines / Menden, Michael [VerfasserIn]; 23 August 2018 (Online-Ressource)
