| |  Online-Ressource |
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| Verfasst von: | Milger-Kneidinger, Katrin [VerfasserIn]  |
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| | Korn, Stephanie [VerfasserIn] |
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| | Buhl, Roland [VerfasserIn] |
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| | Hamelmann, Eckard [VerfasserIn] |
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| | Herth, Felix [VerfasserIn] |
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| | Gappa, Monika [VerfasserIn] |
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| | Drick, Nora [VerfasserIn] |
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| | Fuge, Jan [VerfasserIn] |
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| | Suhling, Hendrik [VerfasserIn] |
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| Titel: | Age- and sex-dependent differences in patients with severe asthma included in the German Asthma Net cohort |
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| Verf.angabe: | Katrin Milger, Stephanie Korn, Roland Buhl, Eckard Hamelmann, Felix JF. Herth, Monika Gappa, Nora Drick, Jan Fuge, Hendrik Suhling |
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| E-Jahr: | 2020 |
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| Jahr: | 3 January 2020 |
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| Umfang: | 6 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Gesehen am 30.03.2020 |
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| Titel Quelle: | Enthalten in: Respiratory medicine |
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| Ort Quelle: | Burlington, Mass. : Harcourt, 1999 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 162(2020) Artikel-Nummer 105858, Seite 1-6 |
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| ISSN Quelle: | 1532-3064 |
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| Abstract: | Background - Severe asthma affects less than 5% of asthmatics, but is associated with high costs and increased mortality. The aim of this study was to assess age- and sex-dependent differences in this patient group. - Methods - Retrospective analysis of 1317 children and adults with severe asthma who are included in the German Asthma Net registry. - Results - There were more adults than children in the registry and patients’ mean age was 52. Apart from children <18 years, there were more women (57%) than men. The age of first diagnosis ranged from 0 to 76 years. 38% of patients had a positive bronchial reversibility after short acting bronchodilators. Quality of life, FEV1 and MEF 25 decreased with older age whereas treatment with oral steroids and monoclonal antibodies increased. An anti-eosinophil treatment was most frequently used in patients aged around 57 years, while an anti-IgE treatment was used in all age-groups including children. There were sex-dependent differences with lower values in men for FEV1, FVC, MEF 25 and DLCO. Yet, women were more frequently unable to work than men due to the disease. - Conclusion - In patients with severe asthma, clinical characteristics, but also treatments differed between age groups and between the sexes, reflecting different phenotypes of the disease. |
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| DOI: | doi:10.1016/j.rmed.2019.105858 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.rmed.2019.105858 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0954611119303725 |
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| | DOI: https://doi.org/10.1016/j.rmed.2019.105858 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Age |
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| | Antibody therapy |
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| | Lung function |
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| | Severe asthma |
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| | Sex |
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| K10plus-PPN: | 1693514346 |
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| Verknüpfungen: | → Zeitschrift |
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Age- and sex-dependent differences in patients with severe asthma included in the German Asthma Net cohort / Milger-Kneidinger, Katrin [VerfasserIn]; 3 January 2020 (Online-Ressource)
