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Verfasst von:Milger-Kneidinger, Katrin [VerfasserIn]   i
 Korn, Stephanie [VerfasserIn]   i
 Buhl, Roland [VerfasserIn]   i
 Hamelmann, Eckard [VerfasserIn]   i
 Herth, Felix [VerfasserIn]   i
 Gappa, Monika [VerfasserIn]   i
 Drick, Nora [VerfasserIn]   i
 Fuge, Jan [VerfasserIn]   i
 Suhling, Hendrik [VerfasserIn]   i
Titel:Age- and sex-dependent differences in patients with severe asthma included in the German Asthma Net cohort
Verf.angabe:Katrin Milger, Stephanie Korn, Roland Buhl, Eckard Hamelmann, Felix JF. Herth, Monika Gappa, Nora Drick, Jan Fuge, Hendrik Suhling
E-Jahr:2020
Jahr:3 January 2020
Umfang:6 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 30.03.2020
Titel Quelle:Enthalten in: Respiratory medicine
Ort Quelle:Burlington, Mass. : Harcourt, 1999
Jahr Quelle:2020
Band/Heft Quelle:162(2020) Artikel-Nummer 105858, Seite 1-6
ISSN Quelle:1532-3064
Abstract:Background - Severe asthma affects less than 5% of asthmatics, but is associated with high costs and increased mortality. The aim of this study was to assess age- and sex-dependent differences in this patient group. - Methods - Retrospective analysis of 1317 children and adults with severe asthma who are included in the German Asthma Net registry. - Results - There were more adults than children in the registry and patients’ mean age was 52. Apart from children <18 years, there were more women (57%) than men. The age of first diagnosis ranged from 0 to 76 years. 38% of patients had a positive bronchial reversibility after short acting bronchodilators. Quality of life, FEV1 and MEF 25 decreased with older age whereas treatment with oral steroids and monoclonal antibodies increased. An anti-eosinophil treatment was most frequently used in patients aged around 57 years, while an anti-IgE treatment was used in all age-groups including children. There were sex-dependent differences with lower values in men for FEV1, FVC, MEF 25 and DLCO. Yet, women were more frequently unable to work than men due to the disease. - Conclusion - In patients with severe asthma, clinical characteristics, but also treatments differed between age groups and between the sexes, reflecting different phenotypes of the disease.
DOI:doi:10.1016/j.rmed.2019.105858
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.rmed.2019.105858
 Volltext: http://www.sciencedirect.com/science/article/pii/S0954611119303725
 DOI: https://doi.org/10.1016/j.rmed.2019.105858
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Age
 Antibody therapy
 Lung function
 Severe asthma
 Sex
K10plus-PPN:1693514346
Verknüpfungen:→ Zeitschrift

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