| Online-Ressource |
Verfasst von: | Milger-Kneidinger, Katrin [VerfasserIn]  |
| Korn, Stephanie [VerfasserIn]  |
| Buhl, Roland [VerfasserIn]  |
| Hamelmann, Eckard [VerfasserIn]  |
| Herth, Felix [VerfasserIn]  |
| Gappa, Monika [VerfasserIn]  |
| Drick, Nora [VerfasserIn]  |
| Fuge, Jan [VerfasserIn]  |
| Suhling, Hendrik [VerfasserIn]  |
Titel: | Age- and sex-dependent differences in patients with severe asthma included in the German Asthma Net cohort |
Verf.angabe: | Katrin Milger, Stephanie Korn, Roland Buhl, Eckard Hamelmann, Felix JF. Herth, Monika Gappa, Nora Drick, Jan Fuge, Hendrik Suhling |
E-Jahr: | 2020 |
Jahr: | 3 January 2020 |
Umfang: | 6 S. |
Illustrationen: | Diagramme |
Fussnoten: | Gesehen am 30.03.2020 |
Titel Quelle: | Enthalten in: Respiratory medicine |
Ort Quelle: | Burlington, Mass. : Harcourt, 1999 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 162(2020) Artikel-Nummer 105858, Seite 1-6 |
ISSN Quelle: | 1532-3064 |
Abstract: | Background - Severe asthma affects less than 5% of asthmatics, but is associated with high costs and increased mortality. The aim of this study was to assess age- and sex-dependent differences in this patient group. - Methods - Retrospective analysis of 1317 children and adults with severe asthma who are included in the German Asthma Net registry. - Results - There were more adults than children in the registry and patients’ mean age was 52. Apart from children <18 years, there were more women (57%) than men. The age of first diagnosis ranged from 0 to 76 years. 38% of patients had a positive bronchial reversibility after short acting bronchodilators. Quality of life, FEV1 and MEF 25 decreased with older age whereas treatment with oral steroids and monoclonal antibodies increased. An anti-eosinophil treatment was most frequently used in patients aged around 57 years, while an anti-IgE treatment was used in all age-groups including children. There were sex-dependent differences with lower values in men for FEV1, FVC, MEF 25 and DLCO. Yet, women were more frequently unable to work than men due to the disease. - Conclusion - In patients with severe asthma, clinical characteristics, but also treatments differed between age groups and between the sexes, reflecting different phenotypes of the disease. |
DOI: | doi:10.1016/j.rmed.2019.105858 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.rmed.2019.105858 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S0954611119303725 |
| DOI: https://doi.org/10.1016/j.rmed.2019.105858 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Age |
| Antibody therapy |
| Lung function |
| Severe asthma |
| Sex |
K10plus-PPN: | 1693514346 |
Verknüpfungen: | → Zeitschrift |
Age- and sex-dependent differences in patients with severe asthma included in the German Asthma Net cohort / Milger-Kneidinger, Katrin [VerfasserIn]; 3 January 2020 (Online-Ressource)