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| Verfasst von: | Vaeggemose, Michael [VerfasserIn]  |
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| | Haakma, W. [VerfasserIn] |
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| | Pham, M. [VerfasserIn] |
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| | Ringgaard, S. [VerfasserIn] |
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| | Tankisi, H. [VerfasserIn] |
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| | Ejskjaer, N. [VerfasserIn] |
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| | Heiland, Sabine [VerfasserIn] |
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| | Poulsen, P. L. [VerfasserIn] |
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| | Andersen, H. [VerfasserIn] |
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| Titel: | Diffusion tensor imaging MR Neurography detects polyneuropathy in type 2 diabetes |
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| Verf.angabe: | M. Vaeggemose, W. Haakma, M. Pham, S. Ringgaard, H. Tankisi, N. Ejskjaer, S. Heiland, P.L. Poulsen, H. Andersen |
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| E-Jahr: | 2020 |
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| Jahr: | [February 2020] |
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| Jahr des Originals: | 2019 |
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| Umfang: | 6 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Available online 12 September 2019 ; Gesehen am 30.03.2020 |
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| Titel Quelle: | Enthalten in: Journal of diabetes and its complications |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1992 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 34 (2020,2) Artikel-Nummer 107439, Seite 1-6 |
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| ISSN Quelle: | 1873-460X |
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| Abstract: | Aim - To evaluate if diffusion-tensor-imaging MR-Neurography (DTI-MRN) can detect lesions of peripheral nerves due to polyneuropathy in patients with type 2 diabetes. - Methods - Ten patients with type 2 diabetes with polyneuropathy (DPN), 10 patients with type 2 diabetes without polyneuropathy (nDPN) as well as 20 healthy controls (HC) were included. DTI-MRN covered proximal (sciatic nerve) and distal regions (tibial nerve) of the lower extremity. Fractional-anisotropy (FA) and diffusivity (mean (MD), axial (AD) and radial (RD)) were calculated and compared to neuropathy severity. Conventional T2-relaxation-time and proton-spin-density data were obtained from a multi-echo SE sequence. Furthermore, we evaluated sensitivity and specificity of DTI-MRN from receiver operating characteristics (ROC). - Results - The proximal and distal FA was lowest in patients with DPN compared with nDPN and HC (p<0.01). Likewise, proximal and distal RD was highest in patients with DPN (p<0.01). MD and AD were also significantly different though less pronounced. ROC curve analyses of DTI separated nDPN and DPN with area-under-the-curve values ranging from 0.65 to 0.98. T2-relaxation-time and proton-spin-density could not differentiate between nDPN and DPN. - Conclusion - DTI-MRN accurately detects DPN by lower nerve FA and higher RD. These alterations are likely to reflect both proximal and distal nerve fiber pathology in patients with type 2 diabetes. |
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| DOI: | doi:10.1016/j.jdiacomp.2019.107439 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.jdiacomp.2019.107439 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1056872718307268 |
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| | DOI: https://doi.org/10.1016/j.jdiacomp.2019.107439 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Diabetes |
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| | Diffusion tensor imaging |
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| | Magnetic resonance neurography |
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| | Neuropathy |
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| | Receiver operating characteristics |
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| | Type 2 diabetes |
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| K10plus-PPN: | 1693515962 |
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| Verknüpfungen: | → Zeitschrift |
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Diffusion tensor imaging MR Neurography detects polyneuropathy in type 2 diabetes / Vaeggemose, Michael [VerfasserIn]; [February 2020] (Online-Ressource)
