| |  Online-Ressource |
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| Verfasst von: | Mayer, Philipp [VerfasserIn]  |
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| | Linnebacher, Alica [VerfasserIn] |
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| | Glennemeier-Marke, Hannah [VerfasserIn] |
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| | Marnet, Nicole [VerfasserIn] |
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| | Bergmann, Frank [VerfasserIn] |
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| | Hackert, Thilo [VerfasserIn] |
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| | Klauß, Miriam [VerfasserIn] |
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| | Poth, Tanja [VerfasserIn] |
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| | Gaida, Matthias [VerfasserIn] |
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| Titel: | The microarchitecture of pancreatic cancer as measured by diffusion-weighted magnetic resonance imaging is altered by T cells with a tumor promoting Th17 phenotype |
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| Verf.angabe: | Philipp Mayer, Alica Linnebacher, Hannah Glennemeier-Marke, Nicole Marnet, Frank Bergmann, Thilo Hackert, Miriam Klauss, Tanja Poth and Matthias M. Gaida |
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| E-Jahr: | 2020 |
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| Jahr: | 5 January 2020 |
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| Umfang: | 16 S. |
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| Fussnoten: | Gesehen am 31.03.2020 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 21(2020), 1, Artikel-ID 346, Seite 1-16 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Diffusion-weighted magnetic resonance imaging (DW-MRI) is a diagnostic tool that is increasingly used for the detection and characterization of focal masses in the abdomen, among these, pancreatic ductal adenocarcinoma (PDAC). DW-MRI reflects the microarchitecture of the tissue, and changes in diffusion, which are reflected by changes in the apparent diffusion coefficient (ADC), are mainly attributed to variations in cellular density, glandular formation, and fibrosis. When analyzing the T cell infiltrates, we found an association of a tumor-promoting subpopulation, characterized by the expression of interleukin (IL) 21 and IL26, with high ADC values. Moreover, the presence of IL21+ and IL26+ positive T cells was associated with poor prognosis. Pancreatic cancers—but not healthy pancreatic tissue—expressed receptors for IL21 and IL26, a finding that could be confirmed in pancreatic cell lines. The functionality of these receptors was demonstrated in pancreatic tumor cell lines, which showed phosphorylation of ERK1/2 and STAT3 pathways in response to the respective recombinant interleukins. Moreover, in vitro data showed an increased colony formation of tumor cells. In summary, our data showed an association of IL21+ and IL26+ immune cell infiltration, increased ADC, and aggressive tumor disease, most likely due to the activation of the key cancer signaling pathways ERK1/2 and STAT3 and formation of tumor colonies. |
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| DOI: | doi:10.3390/ijms21010346 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ijms21010346 |
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| | Volltext: https://www.mdpi.com/1422-0067/21/1/346 |
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| | DOI: https://doi.org/10.3390/ijms21010346 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ADC |
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| | DW-MRI |
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| | IL21 |
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| | IL26 |
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| | pancreatic cancer |
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| | tumor microenvironment |
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| K10plus-PPN: | 1693581094 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ microarchitecture of pancreatic cancer as measured by diffusion-weighted magnetic resonance imaging is altered by T cells with a tumor promoting Th17 phenotype / Mayer, Philipp [VerfasserIn]; 5 January 2020 (Online-Ressource)
