| |  Online-Ressource |
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| Verfasst von: | Bormann, Felix [VerfasserIn]  |
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| | Rodríguez Paredes, Manuel [VerfasserIn] |
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| | Lasitschka, Felix [VerfasserIn] |
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| | Edelmann, Dominic [VerfasserIn] |
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| | Musch, Tanja [VerfasserIn] |
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| | Benner, Axel [VerfasserIn] |
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| | Bergman, Yehudit [VerfasserIn] |
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| | Dieter, Sebastian M. [VerfasserIn] |
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| | Ball, Claudia R. [VerfasserIn] |
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| | Glimm, Hanno [VerfasserIn] |
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| | Linhart, Heinz G. [VerfasserIn] |
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| | Lyko, Frank [VerfasserIn] |
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| Titel: | Cell-of-origin DNA methylation signatures are maintained during colorectal carcinogenesis |
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| Verf.angabe: | Felix Bormann, Manuel Rodríguez-Paredes, Felix Lasitschka, Dominic Edelmann, Tanja Musch, Axel Benner, Yehudit Bergman, Sebastian M. Dieter, Claudia R. Ball, Hanno Glimm, Heinz G. Linhart, and Frank Lyko |
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| E-Jahr: | 2018 |
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| Jahr: | June 12, 2018 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 31.03.2020 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 23(2018), 11, Seite 3407-3418 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, provide opportunities for the molecular analysis of tumors. We have now analyzed DNA methylation patterns in colorectal adenomas and identified three biologically defined subclasses that describe different intestinal crypt differentiation stages. Importantly, colorectal carcinomas could be classified into the same methylation subtypes, reflecting their shared cell types of origin with adenomas. Further data analysis also revealed significantly reduced overall survival for one of the subtypes. Our results provide a concept for understanding the methylation patterns observed in colorectal cancer and provide opportunities for tumor subclassification and patient stratification. |
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| DOI: | doi:10.1016/j.celrep.2018.05.045 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.celrep.2018.05.045 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2211124718307915 |
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| | DOI: https://doi.org/10.1016/j.celrep.2018.05.045 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cell-of-origin |
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| | colorectal adenoma |
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| | colorectal carcinoma |
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| | DNA methylation |
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| | epigenomics |
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| K10plus-PPN: | 1693592401 |
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| Verknüpfungen: | → Zeitschrift |
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Cell-of-origin DNA methylation signatures are maintained during colorectal carcinogenesis / Bormann, Felix [VerfasserIn]; June 12, 2018 (Online-Ressource)
