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Status: Bibliographieeintrag

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Verfasst von:Schmitz, Sarah I. [VerfasserIn]   i
 Widholz, Benedikt [VerfasserIn]   i
 Essers, Christopher [VerfasserIn]   i
 Becker, M. [VerfasserIn]   i
 Tulyaganov, D. U. [VerfasserIn]   i
 Moghaddam-Alvandi, Arash [VerfasserIn]   i
 Gonzalo de Juan, I. [VerfasserIn]   i
 Westhauser, Fabian [VerfasserIn]   i
Titel:Superior biocompatibility and comparable osteoinductive properties
Titelzusatz:sodium-reduced fluoride-containing bioactive glass belonging to the CaO-MgO-SiO2 system as a promising alternative to 45S5 bioactive glass
Verf.angabe:S.I. Schmitz, B. Widholz, C. Essers, M. Becker, D.U. Tulyaganov, A. Moghaddam, I. Gonzalo de Juan, F. Westhauser
E-Jahr:2020
Jahr:13 January 2020
Umfang:11 S.
Fussnoten:Gesehen am 01.04.2020
Titel Quelle:Enthalten in: Bioactive materials
Ort Quelle:[Bejing] : KeAi Publishing, 2016
Jahr Quelle:2020
Band/Heft Quelle:5(2020), 1, Seite 55-65
ISSN Quelle:2452-199X
Abstract:Bioactive glasses (BGs) are promising bone substitute materials. However, under certain circumstances BGs such as the well-known 45S5 Bioglass® (composition in wt%: 45.0 SiO2, 24.5 Na2O, 24.5 CaO, 6.0 P2O5) act cytotoxic due to a strong increase in pH caused by a burst release of sodium ions. A potential alternative is a sodium-reduced fluoride-containing BG belonging to the CaO-MgO-SiO2 system, namely BG1d-BG (composition in wt%: 46.1 SiO2, 28.7 CaO, 8.8 MgO, 6.2 P2O5, 5.7 CaF2, 4.5 Na2O), that has already been evaluated in-vitro, in-vivo and in preliminary clinical trials. Before further application, however, BG1d-BG should be compared to the benchmark amongst BGs, the 45S5 Bioglass® composition, to classify its effect on cell viability, proliferation and osteogenic differentiation of human mesenchymal stem cells (MSCs). Therefore, in this study, the biocompatibility and osteogenic potential of both BGs were investigated in an indirect and direct culture setting to assess the effect of the ionic dissolution products and the BGs’ physical presence on the cells. The results indicated an advantage of BG1d-BG over 45S5 Bioglass® regarding cell viability and proliferation. Both BGs induced an earlier onset of osteogenic differentiation and accelerated the expression of late osteoblast marker genes compared to the control group. In conclusion, BG1d-BG is an attractive candidate for further experimental investigation. The basic mechanisms behind the different impact on cell behavior should be assessed in further detail, e.g. by further alteration of the BG compositions.
DOI:doi:10.1016/j.bioactmat.2019.12.005
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.bioactmat.2019.12.005
 Volltext: http://www.sciencedirect.com/science/article/pii/S2452199X19300738
 DOI: https://doi.org/10.1016/j.bioactmat.2019.12.005
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:45S5 Bioglass®
 Bone tissue engineering
 Fluoride-containing bioactive glass
 Human mesenchymal stromal cells
 Sodium-reduced bioactive glass
K10plus-PPN:1693664585
Verknüpfungen:→ Zeitschrift

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