| |  Online-Ressource |
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| Verfasst von: | Zhao, Haiyu [VerfasserIn]  |
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| | Braunbeck, Thomas [VerfasserIn] |
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| Titel: | Modulation of DNA repair systems in blind cavefish during evolution in constant darkness |
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| Verf.angabe: | Haiyu Zhao, Giuseppe Di Mauro, Sebastian Lungu-Mitea, Pietro Negrini, Andrea Maria Guarino, Elena Frigato, Thomas Braunbeck, Hongju Ma, Tilman Lamparter, Daniela Vallone, Cristiano Bertolucci, and Nicholas S. Foulkes |
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| E-Jahr: | 2018 |
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| Jahr: | 11 October 2018 |
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| Umfang: | 19 S. |
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| Teil: | volume:28 |
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| | year:2018 |
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| | number:20 |
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| | pages:3229-3243 |
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| | extent:19 |
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| Fussnoten: | Gesehen am 02.04.2020 |
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| Titel Quelle: | Enthalten in: Current biology |
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| Ort Quelle: | London : Current Biology Ltd., 1991 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 28(2018,20) Seite 3229-3243, e1-e4, 19 Seiten |
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| ISSN Quelle: | 1879-0445 |
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| Abstract: | <h2>Summary</h2><p>How the environment shapes the function and evolution of DNA repair systems is poorly understood. In a comparative study using zebrafish and the Somalian blind cavefish, <i>Phreatichthys andruzzii</i>, we reveal that during evolution for millions of years in continuous darkness, photoreactivation DNA repair function has been lost in <i>P. andruzzii</i>. We demonstrate that this loss results in part from loss-of-function mutations in pivotal DNA-repair genes. Specifically, C-terminal truncations in <i>P. andruzzii</i> DASH and 6-4 photolyase render these proteins predominantly cytoplasmic, with consequent loss in their functionality. In addition, we reveal a general absence of light-, UV-, and ROS-induced expression of <i>P. andruzzii</i> DNA-repair genes. This results from a loss of function of the D-box enhancer element, which coordinates and enhances DNA repair in response to sunlight. Our results point to <i>P. andruzzii</i> being the only species described, apart from placental mammals, that lacks the highly evolutionary conserved photoreactivation function. We predict that in the DNA repair systems of <i>P. andruzzii</i>, we may be witnessing the first stages in a process that previously occurred in the ancestors of placental mammals during the Mesozoic era.</p> |
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| DOI: | doi:10.1016/j.cub.2018.08.039 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.cub.2018.08.039 |
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| | Volltext: https://www.cell.com/current-biology/abstract/S0960-9822(18)31123-0 |
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| | DOI: https://doi.org/10.1016/j.cub.2018.08.039 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1693666286 |
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| Verknüpfungen: | → Zeitschrift |
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Modulation of DNA repair systems in blind cavefish during evolution in constant darkness / Zhao, Haiyu [VerfasserIn]; 11 October 2018 (Online-Ressource)
