Macular choroidal small-vessel layer, Sattler’s layer and Haller’s layer thicknesses

• Verfasst von: Zhao, Jing [VerfasserIn]
• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Titel: Macular choroidal small-vessel layer, Sattler’s layer and Haller’s layer thicknesses
• Titelzusatz: the Beijing Eye Study
• Verf.angabe: Jing Zhao, Ya Xing Wang, Qi Zhang, Wen Bin Wei, Liang Xu & Jost B. Jonas
• E-Jahr: 2018
• Jahr: 13 March 2018
• Umfang: 14 S.
• Fussnoten: Gesehen am 03.04.2020
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Springer Nature, 2011
• Jahr Quelle: 2018
• Band/Heft Quelle: 8(2018) Artikel-Nummer 4411, 14 Seiten
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-018-22745-4
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1693666855

Abstract

To study macular choroidal layer thickness, 3187 study participants from the population-based Beijing Eye Study underwent spectral-domain optical coherence tomography with enhanced depth imaging for thickness measurements of the macular small-vessel layer, including the choriocapillaris, medium-sized choroidal vessel layer (Sattler’s layer) and large choroidal vessel layer (Haller’s layer). In multivariate analysis, greater thickness of all three choroidal layers was associated (all P < 0.05) with higher prevalence of age-related macular degeneration (AMD) (except for geographic atrophy), while it was not significantly (all P > 0.05) associated with the prevalence of open-angle glaucoma or diabetic retinopathy. There was a tendency (0.07 > P > 0.02) toward thinner choroidal layers in chronic angle-closure glaucoma. The ratio of small-vessel layer thickness to total choroidal thickness increased (P < 0.001; multivariate analysis) with older age and longer axial length, while the ratios of Sattler’s layer and Haller’s layer thickness to total choroidal thickness decreased. A higher ratio of small-vessel layer thickness to total choroidal thickness was significantly associated with a lower prevalence of AMD (early type, intermediate type, late geographic type). Axial elongation-associated and aging-associated choroidal thinning affected Haller’s and Sattler’s layers more markedly than the small-vessel layer. Non-exudative and exudative AMD, except for geographic atrophy, was associated with slightly increased choroidal thickness.