Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory

• Verfasst von: Pfeiffer, Paul [VerfasserIn]
• Verfasst von: Egorov, Alexei [VerfasserIn]
• Verfasst von: Lorenz, Franziska [VerfasserIn]
• Verfasst von: Schleimer, Jan-Hendrik [VerfasserIn]
• Verfasst von: Draguhn, Andreas [VerfasserIn]
• Verfasst von: Schreiber, Susanne [VerfasserIn]
• Titel: Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory
• Verf.angabe: Paul Pfeiffer, Alexei V Egorov, Franziska Lorenz, Jan-Hendrik Schleimer, Andreas Draguhn, Susanne Schreiber
• E-Jahr: 2020
• Jahr: 07 February 2020
• Umfang: 27 S.
• Fussnoten: Gesehen am 01.04.2020
• Titel Quelle: Enthalten in: eLife
• Ort Quelle: Cambridge : eLife Sciences Publications, 2012
• Jahr Quelle: 2020
• Band/Heft Quelle: 9(2020), Artikel-ID e49974, Seite 1-27
• ISSN Quelle: 2050-084X
• DOI: doi:10.7554/eLife.49974
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cellular memory
• Sach-SW: cooperative ion channels
• Sach-SW: dynamic clamp
• K10plus-PPN: 1693693674

Abstract

Across biological systems, cooperativity between proteins enables fast actions, supra-linear responses, and long-lasting molecular switches. In the nervous system, however, the function of cooperative interactions between voltage-dependent ionic channels remains largely unknown. Based on mathematical modeling, we here demonstrate that clusters of strongly cooperative ion channels can plausibly form bistable conductances. Consequently, clusters are permanently switched on by neuronal spiking, switched off by strong hyperpolarization, and remain in their state for seconds after stimulation. The resulting short-term memory of the membrane potential allows to generate persistent firing when clusters of cooperative channels are present together with non-cooperative spike-generating conductances. Dynamic clamp experiments in rodent cortical neurons confirm that channel cooperativity can robustly induce graded persistent activity - a single-cell based, multistable mnemonic firing mode experimentally observed in several brain regions. We therefore propose that ion channel cooperativity constitutes an efficient cell-intrinsic implementation for short-term memories at the voltage level.