Familial ovarian cancer clusters with other cancers

• Verfasst von: Zheng, Guoqiao [VerfasserIn]
• Verfasst von: Yu, Hongyao [VerfasserIn]
• Verfasst von: Försti, Asta [VerfasserIn]
• Verfasst von: Hemminki, Kari [VerfasserIn]
• Titel: Familial ovarian cancer clusters with other cancers
• Verf.angabe: Guoqiao Zheng, Hongyao Yu, Anna Kanerva, Asta Försti, Kristina Sundquist, & Kari Hemminki
• E-Jahr: 2018
• Jahr: 01 August 2018
• Umfang: 10 S.
• Fussnoten: Gesehen am 03.04.2020
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Macmillan Publishers Limited, part of Springer Nature, 2011
• Jahr Quelle: 2018
• Band/Heft Quelle: 8(2018) Artikel-Nummer 11561, 10 Seiten
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-018-29888-4
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1693698498

Abstract

Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patients affected by other cancers, and conversely, risks for other cancers in families with (histology-specific) ovarian cancer patients. Eight discordant cancers were associated with ovarian cancer risk, of which family history of breast cancer showed a dose-response (P-trend <0.0001). Conversely, risks of eight types of cancer increased in families with ovarian cancer patients, and dose-responses were shown for risks of liver (P-trend = 0.0083) and breast cancers (P-trend <0.0001) and cancer of unknown primary (P-trend = 0.0157). Some cancers were only associated with histology-specific ovarian cancers, e.g. endometrial cancer was only associated with endometrioid type but with highest significance. Novel associations with virus-linked cancers of the nose and male and female genitals were found. The results suggest that ovarian cancer shares susceptibility with a number of other cancers. This might alert genetic counselors and challenge approaches for gene and gene-environment identification.