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Verfasst von:Aninditha, Kynann [VerfasserIn]   i
 Weber, Klaus-Josef [VerfasserIn]   i
 Brons, Stephan [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Hauswald, Henrik [VerfasserIn]   i
Titel:In vitro sensitivity of malignant melanoma cells lines to photon and heavy ion radiation
Verf.angabe:K.P. Aninditha, K.J. Weber, S. Brons, J. Debus, H. Hauswald
E-Jahr:2019
Jahr:8 June 2019
Umfang:6 S.
Fussnoten:Gesehen am 02.04.2020
Titel Quelle:Enthalten in: Clinical and translational radiation oncology
Ort Quelle:Amsterdam : Elsevier, 2016
Jahr Quelle:2019
Band/Heft Quelle:17(2019), Seite 51-56
ISSN Quelle:2405-6308
Abstract:Background - The role of radiotherapy in malignant melanoma is still in discussion due to its relative resistance to radiation. In various literature, heavy ions show a higher relative biological effectiveness than photons. The aim of this work is to evaluate the radiotherapeutical effect from photons as well as heavy ions on malignant melanoma cells and to indicate the possible radiosensitivity based on its proliferation-inhibitory effect. - Methods - Two different cell lines of malignant melanoma, WM115 (primary tumor) and WM266-4 (metastatic site, skin) were used in this in vitro study. The cells were treated with photons or heavy ions (C12 and O16 ions). Cell-proliferation assay using hemocytometer was used for the quantitative and qualitative evaluation of cell growth. Furthermore, flow cytometry was also used to analyze the cell cycle distribution. - Results - Heavy ions compared to photons and between the two heavy ion modalities, O16 ions showed an improved suppression of cell growth in both cell lines. Furthermore, a G2/M arrest was detected in both cell lines after all radiotherapy modalities - with the arrest increasing with the dose applied. - Conclusion - Heavy ions showed a greater inhibitory effect on cell proliferation compared to photons and an increased G2/M arrest. Therefore, C12 and O16 heavy ions might overcome the relative radioresistance of malignant melanoma to photons. Further research is warranted.
DOI:doi:10.1016/j.ctro.2019.06.002
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.ctro.2019.06.002
 Volltext: http://www.sciencedirect.com/science/article/pii/S2405630819300217
 DOI: https://doi.org/10.1016/j.ctro.2019.06.002
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cell experiment
 In vitro
 Ion beam therapy
 Malignant melanoma
 Particle beam therapy
 Radiotherapy
K10plus-PPN:1693805723
Verknüpfungen:→ Zeitschrift

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