Revealing age-related changes of adult hippocampal neurogenesis using mathematical models

• Verfasst von: Ziebell, Frederik [VerfasserIn]
• Verfasst von: Dehler, Sascha [VerfasserIn]
• Verfasst von: Martín-Villalba, Ana [VerfasserIn]
• Verfasst von: Marciniak-Czochra, Anna [VerfasserIn]
• Titel: Revealing age-related changes of adult hippocampal neurogenesis using mathematical models
• Verf.angabe: Frederik Ziebell, Sascha Dehler, Ana Martin-Villalba and Anna Marciniak-Czochra
• E-Jahr: 2018
• Jahr: January 8, 2018
• Fussnoten: Gesehen am 23.06.2020
• Titel Quelle: Enthalten in: Development <Cambridge>
• Ort Quelle: Cambridge : The Company of Biologists, 1953
• Jahr Quelle: 2018
• Band/Heft Quelle: 145(2018,1) Artikel-Nummer dev.153544, 12 Seiten
• ISSN Quelle: 1477-9129
• DOI: doi:10.1242/dev.153544
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1693814471

Abstract

Skip to Next Section - New neurons are continuously generated in the dentate gyrus of the adult hippocampus. This continuous supply of newborn neurons is important to modulate cognitive functions. Yet the number of newborn neurons declines with age. Increasing Wnt activity upon loss of dickkopf 1 can counteract both the decline of newborn neurons and the age-related cognitive decline. However, the precise cellular changes underlying the age-related decline or its rescue are fundamentally not understood. The present study combines a mathematical model and experimental data to address features controlling neural stem cell (NSC) dynamics. We show that available experimental data fit a model in which quiescent NSCs may either become activated to divide or may undergo depletion events, such as astrocytic transformation and apoptosis. Additionally, we demonstrate that old NSCs remain quiescent longer and have a higher probability of becoming re-activated than depleted. Finally, our model explains that high NSC-Wnt activity leads to longer time in quiescence while enhancing the probability of activation. Altogether, our study shows that modulation of the quiescent state is crucial to regulate the pool of stem cells throughout the life of an animal.