FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation

• Verfasst von: Richter, Kai [VerfasserIn]
• Verfasst von: Kschonsak, Yvonne T. [VerfasserIn]
• Verfasst von: Vodicska, Barbara [VerfasserIn]
• Verfasst von: Hoffmann, Ingrid [VerfasserIn]
• Titel: FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation
• Verf.angabe: Kai T. Richter, Yvonne T. Kschonsak, Barbara Vodicska, Ingrid Hoffmann
• Jahr: 2020
• Jahr des Originals: 2019
• Umfang: 15 S.
• Fussnoten: Published online: 8 July 2019 ; Gesehen am 02.04.2020
• Titel Quelle: Enthalten in: Cell death and differentiation
• Ort Quelle: Houndmills, Basingstoke : Nature Publishing Group, 1997
• Jahr Quelle: 2020
• Band/Heft Quelle: 27(2020), 2, Seite 758-772
• ISSN Quelle: 1476-5403
• DOI: doi:10.1038/s41418-019-0385-7
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1693821214

Abstract

Cell fate decision upon prolonged mitotic arrest induced by microtubule-targeting agents depends on the activity of the tumor suppressor and F-box protein FBXW7. FBXW7 promotes mitotic cell death and prevents premature escape from mitosis through mitotic slippage. Mitotic slippage is a process that can cause chemoresistance and tumor relapse. Therefore, understanding the mechanisms that regulate the balance between mitotic cell death and mitotic slippage is an important task. Here we report that FBXW7 protein levels markedly decline during extended mitotic arrest.