Occupational UV-exposure is a major risk factor for basal cell carcinoma

• Verfasst von: Schmitt, Jochen Maximilian [VerfasserIn]
• Verfasst von: Haufe, Eva [VerfasserIn]
• Verfasst von: Trautmann, Freya [VerfasserIn]
• Verfasst von: Schulze, Hans-Joachim [VerfasserIn]
• Verfasst von: Elsner, Peter [VerfasserIn]
• Verfasst von: Drexler, Hans [VerfasserIn]
• Verfasst von: Bauer, Andrea [VerfasserIn]
• Verfasst von: Letzel, Stephan [VerfasserIn]
• Verfasst von: John, Swen Malte [VerfasserIn]
• Verfasst von: Fartasch, Manigé [VerfasserIn]
• Verfasst von: Brüning, Thomas [VerfasserIn]
• Verfasst von: Seidler, Andreas [VerfasserIn]
• Verfasst von: Dugas-Breit, Susanne [VerfasserIn]
• Verfasst von: Gina, Michal [VerfasserIn]
• Verfasst von: Weistenhöfer, Wobbeke [VerfasserIn]
• Verfasst von: Bachmann, Klaus [VerfasserIn]
• Verfasst von: Bruhn, Ilka [VerfasserIn]
• Verfasst von: Lang, Berenice Mareen [VerfasserIn]
• Verfasst von: Bonness, Sonja [VerfasserIn]
• Verfasst von: Allam, Jean-Pierre [VerfasserIn]
• Verfasst von: Grobe, William [VerfasserIn]
• Verfasst von: Stange, Thoralf [VerfasserIn]
• Verfasst von: Westerhausen, Stephan [VerfasserIn]
• Verfasst von: Knuschke, Peter [VerfasserIn]
• Verfasst von: Wittlich, Marc [VerfasserIn]
• Verfasst von: Diepgen, Thomas L. [VerfasserIn]
• Titel: Occupational UV-exposure is a major risk factor for basal cell carcinoma
• Titelzusatz: results of the population-based case-control study FB-181
• Verf.angabe: Jochen Schmitt, MD, MPH, Eva Haufe, PhD, Freya Trautmann, MSc, Hans-Joachim Schulze, MD, Peter Elsner, MD, Hans Drexler, MD, Andrea Bauer, MD, MPH, Stephan Letzel, MD, Swen Malte John, MD, Manigé Fartasch, MD, Thomas Brüning, MD, Andreas Seidler, MD, MPH, Susanne Dugas-Breit, MD, Michal Gina, MD, Wobbeke Weistenhöfer, MD, Klaus Bachmann, MD, Ilka Bruhn, MD, Berenice Mareen Lang, MD, Sonja Bonness, MD, Jean Pierre Allam, MD, William Grobe, MD,Thoralf Stange, BSc, Stephan Westerhausen, BSc, Peter Knuschke, MSc, Marc Wittlich, PhD, and Thomas Ludwig Diepgen, MD, for the FB 181 Study Group
• E-Jahr: 2018
• Jahr: January 2018
• Umfang: 8 S.
• Fussnoten: Gesehen am 02.04.2020
• Titel Quelle: Enthalten in: Journal of occupational and environmental medicine
• Ort Quelle: Baltimore, Md. : Lippincott Williams & Wilkins, 1995
• Jahr Quelle: 2018
• Band/Heft Quelle: 60(2018), 1, Seite 36-43
• ISSN Quelle: 1536-5948
• DOI: doi:10.1097/JOM.0000000000001217
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1693830159

Abstract

Objective: The aim of this study was to investigate the role of occupational and nonoccupational ultraviolet (UV)-exposure concerning the development f basal cell carcinoma (BCC). Methods: We undertook a population-based multicenter case–control study. Patients with first incident BCC (n¼836) were propensity score matched by age and sex to controls without skin cancer (n¼836). Sociodemographic characteristics, clinical characteristics, and lifetime UV-exposure were assessed by trained investigators. The differential estimation of occupational and nonoccupational UV-exposure dosages was based on validated instruments and established reference values. Associations were assessed using multivariable-adjusted conditional logistic regression models. Results: Individuals with high levels of occupational UV-exposure were at significantly increased BCC-risk compared with individuals with low [odds ratio (OR) 1.84; 95% confidence interval (95% CI) 1.19 to 2.83 and moderate (OR 1.97; 95% CI 1.20 to 3.22) occupational UV-exposure. Nonoccupational UVexposure was not independently associated with BCC. Conclusion: Skin cancer prevention strategies should be expanded to the occupational setting.