Online-Ressource | |
Verfasst von: | Sprave, Tetyana [VerfasserIn] |
Verma, Vivek [VerfasserIn] | |
Förster, Robert [VerfasserIn] | |
Schlampp, Ingmar [VerfasserIn] | |
Hees, Katharina [VerfasserIn] | |
Bruckner, Thomas [VerfasserIn] | |
Bostel, Tilman [VerfasserIn] | |
El-Shafie, Rami [VerfasserIn] | |
Nicolay, Nils [VerfasserIn] | |
Debus, Jürgen [VerfasserIn] | |
Rief, Harald [VerfasserIn] | |
Titel: | Quality of life and radiation-induced late toxicity following intensity-modulated versus three-dimensional conformal radiotherapy for patients with spinal bone metastases |
Titelzusatz: | results of a randomized trial |
Verf.angabe: | Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Katharina Hees, Thomas Bruckner, Tilman Bostel, Rami El Shafie, Nils Henrik Nicolay, Jürgen Debus, Harald Rief |
E-Jahr: | 2018 |
Jahr: | August 2018 |
Umfang: | 8 S. |
Fussnoten: | Gesehen am 03.04.2020 |
Titel Quelle: | Enthalten in: Anticancer research |
Ort Quelle: | Attiki : [Verlag nicht ermittelbar], 2004 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 38(2018), 8, Seite 4953-4960 |
ISSN Quelle: | 1791-7530 |
Abstract: | BACKGROUND/AIM: Quality of life (QOL) is becoming increasingly important to appraise the value of a particular oncologic intervention. This was a prespecified secondary analysis of a randomized trial (NCT02832830) of intensity-modulated radiotherapy (IMRT) versus conventional three-dimensional conformal radiotherapy (3DCRT) as part of palliative management of symptomatic spinal metastases. This study examined QOL, fatigue, emotional distress, and late toxicities between patients having received IMRT versus 3DCRT. - MATERIALS AND METHODS: Sixty patients were enrolled in this single-institutional randomized exploratory trial in which all patients received 30 Gy in 10 fractions. The EORTC QLQ-BM22, EORTC QLQ-FA13, and QSC-R10 questionnaires were utilized to evaluate QOL, fatigue, and emotional distress, respectively; endpoints were evaluated at baseline, and at 3, and 6 months. Late (6 months) toxicities were assessed according to the LENT-SOMA criteria. - RESULTS: Mean follow-up was 192 days (IQR=77-285). Although QOL was similar between groups, patients in the IMRT arm experienced lower physical (p=0.011) and emotional (p=0.017) fatigue at 6 months. Emotional distress was also lower in IMRT-treated patients after six months (p=0.039). Cohen's effect size confirmed the clinically significant improvement of these findings. Late toxicities occurred infrequently and were similar between arms. - CONCLUSION: This is the first randomized study evaluating QOL between IMRT and 3DCRT to palliate vertebral metastases. IMRT resulted in reduced physical and emotional fatigue as well as emotional distress. IMRT should be further studied for these patients given these outcomes. |
DOI: | doi:10.21873/anticanres.12813 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext: https://doi.org/10.21873/anticanres.12813 |
DOI: https://doi.org/10.21873/anticanres.12813 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Affective Symptoms |
Aged | |
Fatigue | |
Female | |
Humans | |
intensity-modulated radiotherapy | |
Male | |
Middle Aged | |
palliative radiotherapy | |
Prospective Studies | |
quality of life | |
Quality of Life | |
Radiotherapy, Conformal | |
Radiotherapy, Intensity-Modulated | |
Spinal metastases | |
Spinal Neoplasms | |
Surveys and Questionnaires | |
toxicity | |
K10plus-PPN: | 169400001X |
Verknüpfungen: | → Zeitschrift |