| |  Online-Ressource |
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| Verfasst von: | Sriram, Ashwin [VerfasserIn]  |
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| | Bohlen, Jonathan [VerfasserIn] |
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| | Teleman, Aurelio A. [VerfasserIn] |
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| Titel: | Translation acrobatics |
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| Titelzusatz: | how cancer cells exploit alternate modes of translational initiation |
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| Verf.angabe: | Ashwin Sriram, Jonathan Bohlen & Aurelio A Teleman |
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| E-Jahr: | 2018 |
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| Jahr: | 17 September 2018 |
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| Teil: | volume:19 |
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| | year:2018 |
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| | number:10 |
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| Fussnoten: | Gesehen am 03.04.2020 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationEMBO reports |
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| Ort Quelle: | Heidelberg : EMBO Press, 2000 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 19(2018,10) Artikel-Nummer e45947, 19 Seiten |
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| ISSN Quelle: | 1469-3178 |
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| Abstract: | Recent work has brought to light many different mechanisms of translation initiation that function in cells in parallel to canonical cap‐dependent initiation. This has important implications for cancer. Canonical cap‐dependent translation initiation is inhibited by many stresses such as hypoxia, nutrient limitation, proteotoxic stress, or genotoxic stress. Since cancer cells are often exposed to these stresses, they rely on alternate modes of translation initiation for protein synthesis and cell growth. Cancer mutations are now being identified in components of the translation machinery and in cis‐regulatory elements of mRNAs, which both control translation of cancer‐relevant genes. In this review, we provide an overview on the various modes of non‐canonical translation initiation, such as leaky scanning, translation re‐initiation, ribosome shunting, IRES‐dependent translation, and m6A‐dependent translation, and then discuss the influence of stress on these different modes of translation. Finally, we present examples of how these modes of translation are dysregulated in cancer cells, allowing them to grow, to proliferate, and to survive, thereby highlighting the importance of translational control in cancer. |
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| DOI: | doi:10.15252/embr.201845947 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.15252/embr.201845947 |
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| | Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172470/ |
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| | DOI: https://doi.org/10.15252/embr.201845947 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1694042561 |
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| Verknüpfungen: | → Zeitschrift |
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Translation acrobatics / Sriram, Ashwin [VerfasserIn]; 17 September 2018 (Online-Ressource)
