The UGT1A1*28 gene variant predicts long-term mortality in patients undergoing coronary angiography

• Verfasst von: Zulus, Barbara [VerfasserIn]
• Verfasst von: Kleber, Marcus E. [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Titel: The UGT1A1*28 gene variant predicts long-term mortality in patients undergoing coronary angiography
• Verf.angabe: Barbara Zulus, Gerda Grünbacher, Marcus E. Kleber, Winfried März and Wilfried Renner
• Jahr: 2018
• Jahr des Originals: 2017
• Umfang: 5 S.
• Fussnoten: published online December 7, 2017 ; Gesehen am 03.04.2020
• Titel Quelle: Enthalten in: Clinical chemistry and laboratory medicine
• Ort Quelle: Berlin [u.a.] : De Gruyter, 1998
• Jahr Quelle: 2018
• Band/Heft Quelle: 56(2018), 4, Seite 560-564
• ISSN Quelle: 1437-4331
• DOI: doi:10.1515/cclm-2017-0692
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1694064425

Abstract

<section class="abstract"><h2 class="abstractTitle text-title my-1" id="d791e2">Abstract</h2><div id="j_cclm-2017-0692_s_999_w2aab2b8c76b1b7b1aab1c16b1Aa" class="section"><h3 class="abstractTitle text-title my-1" id="d791e5">Background:</h3><p>Uridine diphosphate glycosyltransferases 1A1 (UGT1A1) plays an essential role in detoxification and excretion of several endogenous and exogenous compounds. A functional polymorphism in the promoter of the <em>UGT1A1</em> gene (TA repeat insertion, <em>UGT1A1</em>*28, rs3064744) has been associated with reduced <em>UGT1A1</em> enzyme activity. The purpose of the present study was to investigate the role of <em>UGT1A1</em> genotypes in mortality.</p></div><div id="j_cclm-2017-0692_s_998_w2aab2b8c76b1b7b1aab1c16b2Aa" class="section"><h3 class="abstractTitle text-title my-1" id="d791e21">Methods:</h3><p><em>UGT1A1</em> genotypes as well as baseline plasma bilirubin levels were analyzed in participants of the Ludwigshafen Risk and Cardiovascular Health study (n=3316). <em>UGT1A1</em>*28 genotypes were determined on an ABI PRISM 3730 genetic analyzer.</p></div><div id="j_cclm-2017-0692_s_997_w2aab2b8c76b1b7b1aab1c16b3Aa" class="section"><h3 class="abstractTitle text-title my-1" id="d791e30">Results:</h3><p>As expected, <em>UGT1A1</em> genotypes were associated with baseline bilirubin levels (*1/*1 genotype: 9.1±4.6 µmol/L; *1/*28 genotype: 10.8±5.3; *28/*28: 16.9±9.2; p&lt;0.001). During a median follow-up of 10.4 years, 995 subjects (30.0%) died. In a multivariate regression analysis adjusting for age, sex, smoking, type 2 diabetes, dyslipidemia, alanine aminotransferase (ALT) levels and bilirubin levels, the <em>UGT1A1</em>*28 variant predicted lower overall mortality (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.78-0.95; p=0.003). Contrary to expected, higher baseline bilirubin levels predicted increased mortality (HR, 1.014; 95% CI, 1.002-1.025; p=0.019).</p></div><div id="j_cclm-2017-0692_s_996_w2aab2b8c76b1b7b1aab1c16b4Aa" class="section"><h3 class="abstractTitle text-title my-1" id="d791e40">Conclusions:</h3><p>The <em>UGT1A1</em>*28 gene variant is associated with lower mortality rates. The protective effect of the <em>UGT1A1</em>*28 variant likely includes mechanism other than bilirubin metabolism.</p></div></section>