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Verfasst von:Paredes-Cisneros, Isabela [VerfasserIn]   i
 Karger, Christian [VerfasserIn]   i
 Caprile, Paola [VerfasserIn]   i
 Nolte, David [VerfasserIn]   i
 Espinoza, Ignacio [VerfasserIn]   i
 Gago-Arias, Araceli [VerfasserIn]   i
Titel:Simulation of hypoxia PET-tracer uptake in tumours
Titelzusatz:dependence of clinical uptake-values on transport parameters and arterial input function
Verf.angabe:Isabela Paredes-Cisneros, Christian P. Karger, Paola Caprile, David Nolte, Ignacio Espinoza, Araceli Gago-Arias
E-Jahr:2020
Jahr:29 January 2020
Umfang:9 S.
Fussnoten:Gesehen am 03.04.2020
Titel Quelle:Enthalten in: Physica medica
Ort Quelle:Amsterdam : Elsevier, 1996
Jahr Quelle:2020
Band/Heft Quelle:70(2020), Seite 109-117
ISSN Quelle:1724-191X
Abstract:Poor radiotherapy outcome is in many cases related to hypoxia, due to the increased radioresistance of hypoxic tumour cells. Positron emission tomography may be used to non-invasively assess the oxygenation status of the tumour using hypoxia-specific radiotracers. Quantification and interpretation of these images remains challenging, since radiotracer binding and oxygen tension are not uniquely related. Computer simulation is a useful tool to improve the understanding of tracer dynamics and its relation to clinical uptake parameters currently used to quantify hypoxia. In this study, a model for simulating oxygen and radiotracer distribution in tumours was implemented to analyse the impact of physiological transport parameters and of the arterial input function (AIF) on: oxygenation histograms, time-activity curves, tracer binding and clinical uptake-values (tissue-to-blood ratio, TBR, and a composed hypoxia-perfusion metric, FHP). Results were obtained for parallel and orthogonal vessel architectures and for vascular fractions (VFs) of 1% and 3%. The most sensitive parameters were the AIF and the maximum binding rate (Kmax). TBR allowed discriminating VF for different AIF, and FHP for different Kmax, but neither TBR nor FHP were unbiased in all cases. Biases may especially occur in the comparison of TBR- or FHP-values between different tumours, where the relation between measured and actual AIF may vary. Thus, these parameters represent only surrogates rather than absolute measurements of hypoxia in tumours.
DOI:doi:10.1016/j.ejmp.2020.01.012
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.ejmp.2020.01.012
 Volltext: http://www.sciencedirect.com/science/article/pii/S1120179720300144
 DOI: https://doi.org/10.1016/j.ejmp.2020.01.012
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Computer simulation
 Hypoxia tracer uptake
 Positron-emission-tomography (PET)
 Radiotherapy
K10plus-PPN:1694067572
Verknüpfungen:→ Zeitschrift

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