| |  Online-Ressource |
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| Verfasst von: | Schmöhl, Felix [VerfasserIn]  |
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| | Peters, Verena [VerfasserIn] |
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| | Schmitt, Claus P. [VerfasserIn] |
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| | Poschet, Gernot [VerfasserIn] |
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| | Büttner, Michael [VerfasserIn] |
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| | Li, Xiaogang [VerfasserIn] |
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| | Poth, Tanja [VerfasserIn] |
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| | Volk, Nadine [VerfasserIn] |
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| | Morgenstern, Jakob [VerfasserIn] |
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| | Fleming, Thomas [VerfasserIn] |
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| | Nawroth, Peter Paul [VerfasserIn] |
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| | Kroll, Jens [VerfasserIn] |
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| Titel: | CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications |
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| Verf.angabe: | Felix Schmöhl, Verena Peters, Claus Peter Schmitt, Gernot Poschet, Michael Büttner, Xiaogang Li, Tim Weigand, Tanja Poth, Nadine Volk, Jakob Morgenstern, Thomas Fleming, Peter P. Nawroth, Jens Kroll |
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| E-Jahr: | 2019 |
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| Jahr: | 9 May 2019 |
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| Umfang: | 18 S. |
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| Fussnoten: | Gesehen am 06.04.2020 |
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| Titel Quelle: | Enthalten in: Cellular and molecular life sciences |
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| Ort Quelle: | Cham (ZG) : Springer International Publishing AG, 1997 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 76(2019), 22, Seite 4551-4568 |
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| ISSN Quelle: | 1420-9071 |
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| Abstract: | The gene CNDP1 was associated with the development of diabetic nephropathy. Its enzyme carnosinase 1 (CN1) primarily hydrolyzes the histidine-containing dipeptide carnosine but other organ and metabolic functions are mainly unknown. In our study we generated CNDP1 knockout zebrafish, which showed strongly decreased CN1 activity and increased intracellular carnosine levels. Vasculature and kidneys of CNDP1−/− zebrafish were not affected, except for a transient glomerular alteration. Amino acid profiling showed a decrease of certain amino acids in CNDP1−/− zebrafish, suggesting a specific function for CN1 in the amino acid metabolisms. Indeed, we identified a CN1 activity for Ala-His and Ser-His. Under diabetic conditions increased carnosine levels in CNDP1−/− embryos could not protect from respective organ alterations. Although, weight gain through overfeeding was restrained by CNDP1 loss. Together, zebrafish exhibits CN1 functions, while CNDP1 knockout alters the amino acid metabolism, attenuates weight gain but cannot protect organs from diabetic complications. |
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| DOI: | doi:10.1007/s00018-019-03127-z |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00018-019-03127-z |
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| | DOI: https://doi.org/10.1007/s00018-019-03127-z |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1694129136 |
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| Verknüpfungen: | → Zeitschrift |
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CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications / Schmöhl, Felix [VerfasserIn]; 9 May 2019 (Online-Ressource)
