| |  Online-Ressource |
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| Verfasst von: | Schmitzer, Magdalena [VerfasserIn]  |
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| | Winter, Hauke [VerfasserIn] |
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| | Kneidinger, N. [VerfasserIn] |
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| | Meimarakis, G. [VerfasserIn] |
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| | Dick, A. [VerfasserIn] |
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| | Schramm, R. [VerfasserIn] |
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| | Klotz, Laura Valentina [VerfasserIn] |
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| | Preissler, G. [VerfasserIn] |
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| | Strobl, N. [VerfasserIn] |
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| | Dossow, V. von [VerfasserIn] |
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| | Schneider, C. [VerfasserIn] |
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| | Weig, T. [VerfasserIn] |
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| | Hatz, R. [VerfasserIn] |
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| | Kauke, T. [VerfasserIn] |
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| Titel: | Persistence of de novo donor-specific HLA-antibodies after lung transplantation |
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| Titelzusatz: | a potential marker of decreased patient survival |
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| Verf.angabe: | M. Schmitzer, H. Winter, N. Kneidinger, G. Meimarakis, A. Dick, R. Schramm, L. V. Klotz, G. Preissler, N. Strobl, V. von Dossow, C. Schneider, T. Weig, R. Hatz, T. Kauke |
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| Jahr: | 2018 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 06.04.2020 |
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| Titel Quelle: | Enthalten in: HLA |
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| Ort Quelle: | Oxford : Wiley, 2016 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 92(2018), 1, Seite 24-32 |
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| ISSN Quelle: | 2059-2310 |
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| Abstract: | The impact of de novo donor-specific anti-HLA-antibodies (donor-specific antibody [DSA]) on outcomes in lung transplantation is still a matter of debate. We hypothesize that differentiating DSA by persistent and transient appearance may offer an additional risk assessment. The clinical relevance of HLA-antibodies was investigated prospectively in 72 recipients with a median follow-up period of 21 months. The presence of HLA-antibodies was analysed by a single antigen bead assay before and after (3 weeks, 3, 6, 12 and 18 months) transplantation. In 23 patients (32%), de novo DSAs were detected. In 10 of these patients (44%), DSA persisted throughout the follow-up period, whereas 13 of these patients (56%) had transient DSA. There was a trend towards lower 1-year-survival in DSA-positive compared with DSA-negative patients (83% vs 94%; P = 0.199). Remarkably, patients with persistent DSA had significantly reduced survival (1-year survival 60%) compared with both patients without DSA and those with transient DSA (P = 0.005). Persistent DSA represented as an independent prognostic factor for reduced overall survival in multivariate analysis (HR 8.3, 95% CI 1.8-37.0; P = 0.006). Persistence of DSA during the first year after transplantation seems to be more harmful for lung allograft function than transiently detected DSA at an early stage. |
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| DOI: | doi:10.1111/tan.13306 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/tan.13306 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tan.13306 |
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| | DOI: https://doi.org/10.1111/tan.13306 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | DSA |
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| | graft survival |
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| | HLA-antibodies |
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| | lung transplantation |
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| K10plus-PPN: | 1694141896 |
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| Verknüpfungen: | → Zeitschrift |
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Persistence of de novo donor-specific HLA-antibodies after lung transplantation / Schmitzer, Magdalena [VerfasserIn]; 2018 (Online-Ressource)
