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Verfasst von:Pickles, Jessica C. [VerfasserIn]   i
 Kurian, Kathreena M [VerfasserIn]   i
 Nicoll, James A R [VerfasserIn]   i
 Mitchell, Clare [VerfasserIn]   i
 Capper, David [VerfasserIn]   i
 Sill, Martin [VerfasserIn]   i
 Deimling, Andreas von [VerfasserIn]   i
 Pfister, Stefan [VerfasserIn]   i
 Jones, David T. W. [VerfasserIn]   i
Titel:DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment
Titelzusatz:a population-based study
Verf.angabe:Jessica C Pickles, Amy R Fairchild, Thomas J Stone, Lorelle Brownlee, Ashirwad Merve, Shireena A Yasin, Aimee Avery, Saira W Ahmed, Olumide Ogunbiyi, Jamie Gonzalez Zapata, Abigail F Peary, Marie Edwards, Lisa Wilkhu, Carryl Dryden, Dariusz Ladon, Mark Kristiansen, Catherine Rowe, Kathreena M Kurian, James A R Nicoll, Clare Mitchell, Tabitha Bloom, David A Hilton, Safa Al-Sarraj, Lawrence Doey, Paul N Johns, Leslie R Bridges, Aruna Chakrabarty, Azzam Ismail, Nitika Rathi, Khaja Syed, G Alistair Lammie, Clara Limback-Stanic, Colin Smith, Antonia Torgersen, Frances Rae, Rebecca M Hill, Steven C Clifford, Yura Grabovska, Daniel Williamson, Matthew Clarke, Chris Jones, David Capper, Martin Sill, Andreas von Deimling, Stefan M Pfister, David T W Jones, Darren Hargrave, Jane Chalker, Thomas S Jacques
Jahr:2020
Jahr des Originals:2019
Umfang:9 S.
Fussnoten:Available online 27 November 2019 ; Gesehen am 07.04.2020
Titel Quelle:Enthalten in: The lancet child & adolescent health
Ort Quelle:Kidlington, Oxford : Elsevier, 2017
Jahr Quelle:2020
Band/Heft Quelle:4(2020), 2, Seite 121-130
ISSN Quelle:2352-4650
Abstract:Background - Marked variation exists in the use of genomic data in tumour diagnosis, and optimal integration with conventional diagnostic technology remains uncertain despite several studies reporting improved diagnostic accuracy, selection for targeted treatments, and stratification for trials. Our aim was to assess the added value of molecular profiling in routine clinical practice and the impact on conventional and experimental treatments. - Methods - This population-based study assessed the diagnostic and clinical use of DNA methylation-based profiling in childhood CNS tumours using two large national cohorts in the UK. In the diagnostic cohort—which included routinely diagnosed CNS tumours between Sept 1, 2016, and Sept 1, 2018—we assessed how the methylation profile altered or refined diagnosis in routine clinical practice and estimated how this would affect standard patient management. For the archival cohort of diagnostically difficult cases, we established how many cases could be solved using modern standard pathology, how many could only be solved using the methylation profile, and how many remained unsolvable. - Findings - Of 484 patients younger than 20 years with CNS tumours, 306 had DNA methylation arrays requested by the neuropathologist and were included in the diagnostic cohort. Molecular profiling added a unique contribution to clinical diagnosis in 107 (35%; 95% CI 30-40) of 306 cases in routine diagnostic practice—providing additional molecular subtyping data in 99 cases, amended the final diagnosis in five cases, and making potentially significant predictions in three cases. We estimated that it could change conventional management in 11 (4%; 95% CI 2-6) of 306 patients. Among 195 historically difficult-to-diagnose tumours in the archival cohort, 99 (51%) could be diagnosed using standard methods, with the addition of methylation profiling solving a further 34 (17%) cases. The remaining 62 (32%) cases were unresolved despite specialist pathology and methylation profiling. - Interpretation - Together, these data provide estimates of the impact that could be expected from routine implementation of genomic profiling into clinical practice, and indicate limitations where additional techniques will be required. We conclude that DNA methylation arrays are a useful diagnostic adjunct for childhood CNS tumours. - Funding - The Brain Tumour Charity, Children with Cancer UK, Great Ormond Street Hospital Children's Charity, Olivia Hodson Cancer Fund, Cancer Research UK, and the National Institute of Health Research.
DOI:doi:10.1016/S2352-4642(19)30342-6
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/S2352-4642(19)30342-6
 Volltext: http://www.sciencedirect.com/science/article/pii/S2352464219303426
 DOI: https://doi.org/10.1016/S2352-4642(19)30342-6
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1694156230
Verknüpfungen:→ Zeitschrift

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