Novel approach to an early assessment of a patient’s potential for neurological remission after acute spinal cord injury

• Verfasst von: Biglari, Bahram [VerfasserIn]
• Verfasst von: Heller, Raban [VerfasserIn]
• Verfasst von: Hörner, Manuel [VerfasserIn]
• Verfasst von: Sperl, André [VerfasserIn]
• Verfasst von: Bock, Tobias [VerfasserIn]
• Verfasst von: Reible, Bruno [VerfasserIn]
• Verfasst von: Haubruck, Patrick [VerfasserIn]
• Verfasst von: Grützner, Paul Alfred [VerfasserIn]
• Verfasst von: Moghaddam-Alvandi, Arash [VerfasserIn]
• Titel: Novel approach to an early assessment of a patient’s potential for neurological remission after acute spinal cord injury
• Titelzusatz: Analysis of hemoglobin concentration dynamics
• Verf.angabe: Bahram Biglari, Raban Arved Heller, Manuel Hörner, Andre Sperl, Tobias Bock, Bruno Reible, Patrick Haubruck, Paul Alfred Grützner, Arash Moghaddam
• Jahr: 2021
• Umfang: 12 S.
• Fussnoten: Online veröffentlicht: 18. Juni 2019 ; Gesehen am 07.04.2020
• Titel Quelle: Enthalten in: The journal of spinal cord medicine
• Ort Quelle: Abingdon, Oxon : Taylor and Francis, 1995
• Jahr Quelle: 2021
• Band/Heft Quelle: 44(2021), 2, Seite 229-240
• ISSN Quelle: 2045-7723
• DOI: doi:10.1080/10790268.2019.1632060
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biomarker
• Sach-SW: Hemoglobin
• Sach-SW: Neurological remission
• Sach-SW: Traumatic spinal cord injury
• K10plus-PPN: 169417574X

Abstract

Context/objective: Examining hemoglobin (Hb) dynamics with regard to the potential of neurological remission in patients with traumatic spinal cord injury (TSCI).Design: Prospective Clinical Observational Study.Setting: BG Trauma Centre Ludwigshafen, Department of Paraplegiology, Rhineland-Palatinate, Germany.Methods: From 2011 to 2017 a total of 80 patients with acute spinal injury were enrolled and divided into three groups: initial neurological impairment either with (G1; n = 33) or without subsequent neurological remission (G0; n = 35) and vertebral fractures without initial neurological impairment as control group (C; n = 12). Blood samples were taken for 3 months at 11 time-points after injury. Analyses were performed using routine diagnostics.Outcome measures: Multiple logistic regression was used to determine the prognostic value of Hb regarding neurological remission respecting clinical covariates.Results: Data showed elevated mean Hb concentrations in G1 from the third day to 1 month compared to G0, Hb levels were significantly higher in G1 after 3 days (P = 0.03, G1 > G0). The final multiple logistic regression model based on this data predicting the presence of neurological remission resulted in an AUC (area under the curve) of 80.5% (CI: 67.8%-93.2%) in the ROC (receiver operating characteristic) analysis.Conclusion: Elevated Hb concentrations are associated with a higher likelihood of neurological remission. Elevated concentrations of Hb in G1 compared to G0 over time might be linked to both a better initial oxygen supply response and a decreased ECM (extracellular matrix) degradation highlighting the role of Hb as a valuable biomarker for neural regeneration after TSCI.