Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Forschner, Andrea Lydia [VerfasserIn]   i
 Keim, Ulrike [VerfasserIn]   i
 Hofmann, Maja [VerfasserIn]   i
 Spänkuch, Iris [VerfasserIn]   i
 Lomberg, Diana Jasmin [VerfasserIn]   i
 Weide, Benjamin Matthias [VerfasserIn]   i
 Tampouri, Ioanna [VerfasserIn]   i
 Eigentler, Thomas [VerfasserIn]   i
 Müller-Christmann, Christine [VerfasserIn]   i
 Garbe, Claus [VerfasserIn]   i
 Hänßle, Holger [VerfasserIn]   i
Titel:Diagnostic accuracy of dermatofluoroscopy in cutaneous melanoma detection
Titelzusatz:results of a prospective multicentre clinical study in 476 pigmented lesions
Verf.angabe:A. Forschner, U. Keim, M. Hofmann, I. Spänkuch, D. Lomberg, B. Weide, I. Tampouri, T. Eigentler, C. Fink, C. Garbe, and H.A. Haenssle
E-Jahr:2018
Jahr:22 March 2018
Umfang:8 S.
Fussnoten:Gesehen am 07.04.2020
Titel Quelle:Enthalten in: British journal of dermatology
Ort Quelle:Oxford : Oxford University Press, 1892
Jahr Quelle:2018
Band/Heft Quelle:179(2018), 2, Seite 478-485
ISSN Quelle:1365-2133
Abstract:Background Early detection is a key factor in improving survival from melanoma. Today, the clinical diagnosis of cutaneous melanoma is based mostly on visual inspection and dermoscopy. Preclinical studies in freshly excised or paraffin-embedded tissue have shown that the melanin fluorescence spectra after stepwise two-photon excitation, a process termed dermatofluoroscopy, differ between cutaneous melanoma and melanocytic naevi. However, confirmation from a larger prospective clinical study is lacking. Objectives The primary end point of this study was to determine the diagnostic accuracy of dermatofluoroscopy in melanoma detection. Secondary end points included the collection of data for improving the computer algorithm that classifies skin lesions based on melanin fluorescence and the assessment of safety aspects. Methods This was a prospective, blinded, multicentre clinical study in patients with pigmented skin lesions (PSLs) indicated for excision either to rule out or to confirm cutaneous melanoma. All included lesions underwent dermoscopy and dermatofluoroscopy in vivo before lesions were excised and subjected to histopathological examination. Results In total, 369 patients and 476 PSLs were included in the final analysis. In 101 of 476 lesions (21·2%) histopathology revealed melanoma. The observed sensitivity of dermatofluoroscopy was 89·1% (90 of 101 melanomas identified), with an observed specificity of 44·8%. The positive and negative predictive values were 30·3% and 93·9%, respectively. No adverse events occurred. Conclusions Dermatofluoroscopy is a safe and accurate diagnostic method to aid physicians in diagnosing cutaneous melanoma. Limitations arise from largely amelanotic or regressing lesions lacking sufficient melanin fluorescence.
DOI:doi:10.1111/bjd.16565
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1111/bjd.16565
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.16565
 DOI: https://doi.org/10.1111/bjd.16565
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1694179494
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68562504   QR-Code
zum Seitenanfang