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Verfasst von:Rogers, Jack C. [VerfasserIn]   i
 Kirchner, Marietta [VerfasserIn]   i
Titel:White matter microstructure in youths with conduct disorder
Titelzusatz:effects of sex and variation in callous traits
Verf.angabe:Jack C. Rogers, PhD, Karen Gonzalez-Madruga, MSc, Gregor Kohls, PhD, Rosalind H. Baker, PhD,Roberta L. Clanton, PhD, Ruth Pauli, MSc, Philippa Birch, BSc, Alimul I. Chowdhury, PhD,Marietta Kirchner, PhD, Jesper L.R. Andersson, PhD, Areti Smaragdi, PhD, Ignazio Puzzo, PhD,Sarah Baumann, MSc, Nora M. Raschle, PhD, Lynn V. Fehlbaum, MSc, Willeke M. Menks, PhD,Martin Steppan, PhD, Christina Stadler, PhD, Kerstin Konrad, PhD,Christine M. Freitag, MD, PhD (Habilitation), Graeme Fairchild, PhD, Stephane A. De Brito, PhD
E-Jahr:2019
Jahr:April 25, 2019
Umfang:13 S.
Fussnoten:Gesehen am 03.07.2020
Titel Quelle:Enthalten in: American Academy of Child and Adolescent PsychiatryJournal of the American Academy of Child and Adolescent Psychiatry
Ort Quelle:Kidlington [u.a.] : Elsevier, 1987
Jahr Quelle:2019
Band/Heft Quelle:58(2019), 12, Seite 1184-1196
ISSN Quelle:1527-5418
Abstract:Studies using diffusion tensor imaging (DTI) to investigate white matter (WM) microstructure in youths with conduct disorder (CD) have reported disparate findings. We investigated WM alterations in a large sample of youths with CD, and examined the influence of sex and callous-unemotional (CU) traits.</p><h3>Method</h3><p>DTI data were acquired from 124 youths with CD (59 female) and 174 typically developing (TD) youths (103 female) 9 to 18 years of age. Tract-based spatial statistics tested for effects of diagnosis and sex-by-diagnosis interactions. Associations with CD symptoms, CU traits, a task measuring impulsivity, and the impact of comorbidity, and age- and puberty-related effects were examined.</p><h3>Results</h3><p>Youths with CD exhibited higher axial diffusivity in the corpus callosum and lower radial diffusivity and mean diffusivity in the anterior thalamic radiation relative to TD youths. Female and male youths with CD exhibited opposite changes in the left hemisphere within the internal capsule, fornix, posterior thalamic radiation, and uncinate fasciculus. Within the CD group, CD symptoms and callous traits exerted opposing influences on corpus callosum axial diffusivity, with callous traits identified as the unique clinical feature predicting higher axial diffusivity and lower radial diffusivity within the corpus callosum and anterior thalamic radiation, respectively. In an exploratory analysis, corpus callosum axial diffusivity partially mediated the association between callous traits and impulsive responses to emotional faces. Results were not influenced by symptoms of comorbid disorders, and no age- or puberty-related interactions were observed.</p><h3>Conclusion</h3><p>WM alterations within the corpus callosum represent a reliable neuroimaging marker of CD. Sex and callous traits are important factors to consider when examining WM in CD.</p>
DOI:doi:10.1016/j.jaac.2019.02.019
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.jaac.2019.02.019
 Volltext: https://jaacap.org/article/S0890-8567(19)30251-5/abstract
 DOI: https://doi.org/10.1016/j.jaac.2019.02.019
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1694241424
Verknüpfungen:→ Zeitschrift

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