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Verfasst von:Stanisavljević, Andrijana [VerfasserIn]   i
 Perić, Ivana [VerfasserIn]   i
 Gass, Peter [VerfasserIn]   i
 Inta, Dragos [VerfasserIn]   i
 Lang, Undine E. [VerfasserIn]   i
 Borgwardt, Stefan [VerfasserIn]   i
 Filipović, Dragana [VerfasserIn]   i
Titel:Brain sub/region-specific effects of olanzapine on c-Fos expression of chronically socially isolated rats
Verf.angabe:Andrijana Stanisavljević, Ivana Perić, Peter Gass, Dragos Inta, Undine E. Lang, Stefan Borgwardt, Dragana Filipović
E-Jahr:2019
Jahr:17 November 2018
Jahr des Originals:2018
Umfang:20 S.
Fussnoten:Gesehen am 08.04.2020
Titel Quelle:Enthalten in: Neuroscience
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1976
Jahr Quelle:2019
Band/Heft Quelle:396(2019), Seite 46-65
ISSN Quelle:1873-7544
Abstract:Olanzapine (Olz) is an atypical antipsychotic used to treat depression, anxiety and schizophrenia, which can be caused by chronic psychosocial stress. c-Fos protein expression has been used as an indirect marker of neuronal activity in response to various forms of stress or pharmacological treatments. We examined the effects of a 3-week treatment of Olz (7.5mg/kg/day) on c-Fos protein expression in stress-relevant brain sub/regions, its relationship with isolation-induced behavioral changes, and potential sites of Olz action on control and male rats exposed to 6weeks of chronic social isolation (CSIS), an animal model of depression. Olz treatment reversed depression- and anxiety-like behaviors induced by CSIS and suppressed a CSIS-induced increase in the number of c-Fos-positive cells in subregions of the dorsal hippocampus, ventral (v) DG, retrosplenial cortex, and medial prefrontal cortex. In contrast, no change in c-Fos expression was seen in the CA3v, amygdala and thalamic, hypothalamic or striatal subregions in Olz-treated CSIS rats, suggesting different brain sub/regions’ susceptibility to Olz. An increased number of c-Fos-positive cells in the CA1v, amygdala and thalamic, hypothalamic and striatal subregions in controls as well as in the CA1v and subregion of the hypothalamus and nucleus accumbens in Olz-treated CSIS rats was found. Results suggest the activation of brain sub/regions following CSIS that may be involved in depressive and anxiety-like behaviors. Olz treatment showed region-specific effects on neuronal activation. Our data contribute to a better understanding of the mechanisms underlying the CSIS response and potential brain targets of Olz in socially isolated rats.
DOI:doi:10.1016/j.neuroscience.2018.11.015
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.neuroscience.2018.11.015
 Volltext: http://www.sciencedirect.com/science/article/pii/S0306452218307395
 DOI: https://doi.org/10.1016/j.neuroscience.2018.11.015
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:brain sub/regions
 C-fos
 depression- and anxiety-like behaviors
 olanzapine
 social isolation
K10plus-PPN:1694261999
Verknüpfungen:→ Zeitschrift

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