Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Schreiber, Caroline [VerfasserIn]   i
 Saraswati, Supriya [VerfasserIn]   i
 Harkins, Shannon [VerfasserIn]   i
 Gruber, Annette [VerfasserIn]   i
 Cremers, Natascha [VerfasserIn]   i
 Thiele, Wilko [VerfasserIn]   i
 Rothley, Melanie [VerfasserIn]   i
 Plaumann, Diana [VerfasserIn]   i
 Korn, Claudia [VerfasserIn]   i
 Armant, Olivier [VerfasserIn]   i
 Augustin, Hellmut [VerfasserIn]   i
 Sleeman, Jonathan P. [VerfasserIn]   i
Titel:Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling
Verf.angabe:Caroline Schreiber, Supriya Saraswati, Shannon Harkins, Annette Gruber, Natascha Cremers, Wilko Thiele, Melanie Rothley, Diana Plaumann, Claudia Korn, Olivier Armant, Hellmut G. Augustin, Jonathan P. Sleeman
E-Jahr:2019
Jahr:June 27, 2019
Umfang:25 S.
Fussnoten:Gesehen am 08.04.2020
Titel Quelle:Enthalten in: Public Library of SciencePLoS Genetics
Ort Quelle:San Francisco, Calif. : Public Library of Science, 2005
Jahr Quelle:2019
Band/Heft Quelle:15(2019,6) Artikel-Nummer e1008216, 25 Seiten
ISSN Quelle:1553-7404
Abstract:ASAP1 is a multi-domain adaptor protein that regulates cytoskeletal dynamics, receptor recycling and intracellular vesicle trafficking. Its expression is associated with poor prognosis for a variety of cancers, and promotes cell migration, invasion and metastasis. Little is known about its physiological role. In this study, we used mice with a gene-trap inactivated ASAP1 locus to study the functional role of ASAP1 in vivo, and found defects in tissues derived from mesenchymal progenitor cells. Loss of ASAP1 led to growth retardation and delayed ossification typified by enlarged hypertrophic zones in growth plates and disorganized chondro-osseous junctions. Furthermore, loss of ASAP1 led to delayed adipocyte development and reduced fat depot formation. Consistently, deletion of ASAP1 resulted in accelerated chondrogenic differentiation of mesenchymal cells in vitro, but suppressed osteo- and adipogenic differentiation. Mechanistically, we found that FAK/Src and PI3K/AKT signaling is compromised in Asap1GT/GT MEFs, leading to impaired adipogenic differentiation. Dysregulated FAK/Src and PI3K/AKT signaling is also associated with attenuated osteogenic differentiation. Together these observations suggest that ASAP1 plays a decisive role during the differentiation of mesenchymal progenitor cells.
DOI:doi:10.1371/journal.pgen.1008216
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1371/journal.pgen.1008216
 Volltext: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008216
 DOI: https://doi.org/10.1371/journal.pgen.1008216
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adipocyte differentiation
 Adipocytes
 Alizarin staining
 Cell differentiation
 Cell staining
 Embryos
 Ossification
 Stem cells
K10plus-PPN:1694272850
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68563081   QR-Code
zum Seitenanfang