Hepatitis C virus replication

• Verfasst von: Tabata, Keisuke [VerfasserIn]
• Verfasst von: Neufeldt, Christopher [VerfasserIn]
• Verfasst von: Bartenschlager, Ralf [VerfasserIn]
• Titel: Hepatitis C virus replication
• Verf.angabe: Keisuke Tabata, Christopher J. Neufeldt, and Ralf Bartenschlager
• E-Jahr: 2020
• Jahr: MAR 2020
• Umfang: ? S.
• Fussnoten: Gesehen am 08.04.2020
• Titel Quelle: Enthalten in: Cold Spring Harbor perspectives in medicine
• Ort Quelle: Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, 2011
• Jahr Quelle: 2020
• Band/Heft Quelle: 10(2020,3) Artikel-Nummer a037093
• ISSN Quelle: 2157-1422
• DOI: doi:10.1101/cshperspect.a037093
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 3' nontranslated region
• Sach-SW: binding protein
• Sach-SW: coding region
• Sach-SW: de-novo initiation
• Sach-SW: dependent rna-polymerase
• Sach-SW: hcv replication
• Sach-SW: membranous replication
• Sach-SW: nonstructural protein 5a
• Sach-SW: secondary structure
• Sach-SW: untranslated region
• K10plus-PPN: 169427957X

Abstract

Replication and amplification of the viral genome is a key process for all viruses. For hepatitis C virus (HCV), a positive-strand RNA virus, amplification of the viral genome requires the synthesis of a negative-sense RNA template, which is in turn used for the production of new genomic RNA. This process is governed by numerous proteins, both host and viral, as well as distinct lipids and specific RNA elements within the positive- and negative-strand RNAs. Moreover, this process requires specific changes to host cell ultrastructure to create micro-environments conducive to viral replication. This review will focus on describing the processes and factors involved in facilitating or regulating HCV genome replication.