Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| Online-Ressource |
Verfasst von: | Stapper, Zeenna A. [VerfasserIn]  |
| Jahn, Thomas R. [VerfasserIn]  |
Titel: | Changes in glutathione redox potential are linked to Aβ42-induced neurotoxicity |
Verf.angabe: | Zeenna A. Stapper, Thomas R. Jahn |
E-Jahr: | 2018 |
Jahr: | 14 August 2018 |
Umfang: | 8 S. |
Fussnoten: | Gesehen am 08.04.2020 ; Im Titel ist "42" in Aβ42-induced tiefgestellt |
Titel Quelle: | Enthalten in: Cell reports |
Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 24(2018), 7, Seite 1696-1703 |
ISSN Quelle: | 2211-1247 |
Abstract: | Glutathione is the major low-molecular weight thiol of eukaryotic cells. It is central to one of the two major NADPH-dependent reducing systems and is likely to play a role in combating oxidative stress, a process suggested to play a key role in Alzheimer’s disease (AD). However, the nature and relevance of redox changes in the onset and progression of AD are still uncertain. Here, we combine genetically encoded redox sensors with our Drosophila models of amyloid-beta (Aβ) aggregation. We find that changes in glutathione redox potential (EGSH) closely correlate with disease onset and progression. We observe this redox imbalance specifically in neurons, but not in glia cells. EGSH changes and Aβ42 deposition are also accompanied by increased JNK stress signaling. Furthermore, pharmacologic and genetic manipulation of glutathione synthesis modulates Aβ42-mediated neurotoxicity, suggesting a causal relationship between disturbed glutathione redox homeostasis and early AD pathology. |
DOI: | doi:10.1016/j.celrep.2018.07.052 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2018.07.052 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S2211124718311550 |
| DOI: https://doi.org/10.1016/j.celrep.2018.07.052 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Alzheimer’s disease |
| amyloid-beta |
| glutathione redox balance |
| models |
| redox sensors |
K10plus-PPN: | 1694280721 |
Verknüpfungen: | → Zeitschrift |
Changes in glutathione redox potential are linked to Aβ42-induced neurotoxicity / Stapper, Zeenna A. [VerfasserIn]; 14 August 2018 (Online-Ressource)
68563108