Re-irradiation with protons or heavy ions with focus on head and neck, skull base and brain malignancies

• Verfasst von: Seidensaal, Katharina [VerfasserIn]
• Verfasst von: Harrabi, Semi B. [VerfasserIn]
• Verfasst von: Uhl, Matthias [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Titel: Re-irradiation with protons or heavy ions with focus on head and neck, skull base and brain malignancies
• Verf.angabe: Katharina Seidensaal, Semi Ben Harrabi, Matthias Uhl and Juergen Debus
• Jahr: 2020
• Jahr des Originals: 2019
• Umfang: 9 S.
• Fussnoten: Published online: November 12, 2019 ; Gesehen am 13.05.2020
• Titel Quelle: Enthalten in: BJR case reports
• Ort Quelle: London : BIR Publications, 2015
• Jahr Quelle: 2020
• Band/Heft Quelle: 93(2020,1107) Artikel-Nummer 20190516, 9 Seiten
• ISSN Quelle: 2055-7159
• DOI: doi:10.1259/bjr.20190516
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1694421872

Abstract

Re-irradiation can offer a potentially curative solution in case of progression after initial therapy; however, a second course of radiotherapy can be associated with an increased risk of severe side-effects. Particle therapy with protons and especially carbon ions spares surrounding tissue better than most photon techniques, thus it is of high potential for re-irradiation. Irradiation of tumors of the brain, head and neck and skull base involves several delicate risk organs, e.g. optic system, brainstem, salivary gland or swallowing muscles. Adequate local control rates with tolerable side-effects have been described for several tumors of these locations as meningioma, adenoid cystic carcinoma, chordoma or chondrosarcoma and head and neck tumors. High life time doses nonetheless lead to a different scope of side-effects, e.g. an enhanced rate of carotid blow outs has been reported. This review summarizes the current data on particle irradiation of the aforementioned locations and malignancies.