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Status: Bibliographieeintrag

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 Online-Ressource
Verfasst von:Mi, Lan [VerfasserIn]   i
 Hu, Kai [VerfasserIn]   i
 Wen, Xianzi [VerfasserIn]   i
 Sun, Jing [VerfasserIn]   i
 Wu, Aiwen [VerfasserIn]   i
 Wang, Mingliang [VerfasserIn]   i
 Zheng, Minhua [VerfasserIn]   i
 Zang, Lu [VerfasserIn]   i
 Ji, Jiafu [VerfasserIn]   i
Titel:Upregulation of C/EBPα contributes to colorectal cancer growth, metastasis and indicates poor survival outcome
Verf.angabe:Lan Mi, Kai Hu, Xianzi Wen, Jing Sun, Aiwen Wu, Mingliang Wang, Minhua Zheng, Lu Zang, Jiafu Ji
E-Jahr:2018
Jahr:August 1, 2018
Umfang:17 S.
Fussnoten:Gesehen am 14.04.2020
Titel Quelle:Enthalten in: American journal of cancer research
Ort Quelle:Madison, Wis. : e-Century Publ., 2011
Jahr Quelle:2018
Band/Heft Quelle:8(2018), 8, Seite 1449-1465
ISSN Quelle:2156-6976
Abstract:The function and clinical implication of transcription factor CCAAT/enhancer-binding protein α (C/EBPα) in colorectal cancer (CRC) still remains undefined. In fact, C/EBPα has long been considered as a tumor suppressor in hematopoietic system and also found lowly expressed in numerous solid tumors. However, our results here for the first time showed that C/EBPα was unexpectedly upregulated and was an independent prognostic marker for patients with CRC. We therefore aimed to explore the detailed role and mechanisms of C/EBPα in CRC. Our investigation demonstrated that C/EBPα promoted tumor growth both in vitro and in vivo. In addition, suppression of C/EBPα inhibited cell proliferation by inducing G1 phase arrest and inducing apoptosis. Also, C/EBPα enhances CRC cells migration and invasion in vitro as well as metastasis in vivo through regulating EMT. Mechanistically, C/EBPα exerts its oncogenic role by targeting c-Myc/cyclin D1 mediated by β-catenin involved pathway and we provide evidence indicating that cytoplasmic exclusion of C/EBPα might contribute to its oncogenic function in tumor progression. In conclusion, C/EBPα acts as an oncogene in CRC and could be a potential biomarker of colon carcinogenesis.
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:C/EBPα
 colorectal cancer
 EMT
 metastasis
 proliferation
K10plus-PPN:1694473252
Verknüpfungen:→ Zeitschrift

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