Upregulation of C/EBPα contributes to colorectal cancer growth, metastasis and indicates poor survival outcome

• Verfasst von: Mi, Lan [VerfasserIn]
• Verfasst von: Hu, Kai [VerfasserIn]
• Verfasst von: Wen, Xianzi [VerfasserIn]
• Verfasst von: Sun, Jing [VerfasserIn]
• Verfasst von: Wu, Aiwen [VerfasserIn]
• Verfasst von: Wang, Mingliang [VerfasserIn]
• Verfasst von: Zheng, Minhua [VerfasserIn]
• Verfasst von: Zang, Lu [VerfasserIn]
• Verfasst von: Ji, Jiafu [VerfasserIn]
• Titel: Upregulation of C/EBPα contributes to colorectal cancer growth, metastasis and indicates poor survival outcome
• Verf.angabe: Lan Mi, Kai Hu, Xianzi Wen, Jing Sun, Aiwen Wu, Mingliang Wang, Minhua Zheng, Lu Zang, Jiafu Ji
• E-Jahr: 2018
• Jahr: August 1, 2018
• Umfang: 17 S.
• Fussnoten: Gesehen am 14.04.2020
• Titel Quelle: Enthalten in: American journal of cancer research
• Ort Quelle: Madison, Wis. : e-Century Publ., 2011
• Jahr Quelle: 2018
• Band/Heft Quelle: 8(2018), 8, Seite 1449-1465
• ISSN Quelle: 2156-6976
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: C/EBPα
• Sach-SW: colorectal cancer
• Sach-SW: EMT
• Sach-SW: metastasis
• Sach-SW: proliferation
• K10plus-PPN: 1694473252

Abstract

The function and clinical implication of transcription factor CCAAT/enhancer-binding protein α (C/EBPα) in colorectal cancer (CRC) still remains undefined. In fact, C/EBPα has long been considered as a tumor suppressor in hematopoietic system and also found lowly expressed in numerous solid tumors. However, our results here for the first time showed that C/EBPα was unexpectedly upregulated and was an independent prognostic marker for patients with CRC. We therefore aimed to explore the detailed role and mechanisms of C/EBPα in CRC. Our investigation demonstrated that C/EBPα promoted tumor growth both in vitro and in vivo. In addition, suppression of C/EBPα inhibited cell proliferation by inducing G1 phase arrest and inducing apoptosis. Also, C/EBPα enhances CRC cells migration and invasion in vitro as well as metastasis in vivo through regulating EMT. Mechanistically, C/EBPα exerts its oncogenic role by targeting c-Myc/cyclin D1 mediated by β-catenin involved pathway and we provide evidence indicating that cytoplasmic exclusion of C/EBPα might contribute to its oncogenic function in tumor progression. In conclusion, C/EBPα acts as an oncogene in CRC and could be a potential biomarker of colon carcinogenesis.