Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Mi, Lan [VerfasserIn]  |
| Hu, Kai [VerfasserIn]  |
| Wen, Xianzi [VerfasserIn]  |
| Sun, Jing [VerfasserIn]  |
| Wu, Aiwen [VerfasserIn]  |
| Wang, Mingliang [VerfasserIn]  |
| Zheng, Minhua [VerfasserIn]  |
| Zang, Lu [VerfasserIn]  |
| Ji, Jiafu [VerfasserIn]  |
Titel: | Upregulation of C/EBPα contributes to colorectal cancer growth, metastasis and indicates poor survival outcome |
Verf.angabe: | Lan Mi, Kai Hu, Xianzi Wen, Jing Sun, Aiwen Wu, Mingliang Wang, Minhua Zheng, Lu Zang, Jiafu Ji |
E-Jahr: | 2018 |
Jahr: | August 1, 2018 |
Umfang: | 17 S. |
Fussnoten: | Gesehen am 14.04.2020 |
Titel Quelle: | Enthalten in: American journal of cancer research |
Ort Quelle: | Madison, Wis. : e-Century Publ., 2011 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 8(2018), 8, Seite 1449-1465 |
ISSN Quelle: | 2156-6976 |
Abstract: | The function and clinical implication of transcription factor CCAAT/enhancer-binding protein α (C/EBPα) in colorectal cancer (CRC) still remains undefined. In fact, C/EBPα has long been considered as a tumor suppressor in hematopoietic system and also found lowly expressed in numerous solid tumors. However, our results here for the first time showed that C/EBPα was unexpectedly upregulated and was an independent prognostic marker for patients with CRC. We therefore aimed to explore the detailed role and mechanisms of C/EBPα in CRC. Our investigation demonstrated that C/EBPα promoted tumor growth both in vitro and in vivo. In addition, suppression of C/EBPα inhibited cell proliferation by inducing G1 phase arrest and inducing apoptosis. Also, C/EBPα enhances CRC cells migration and invasion in vitro as well as metastasis in vivo through regulating EMT. Mechanistically, C/EBPα exerts its oncogenic role by targeting c-Myc/cyclin D1 mediated by β-catenin involved pathway and we provide evidence indicating that cytoplasmic exclusion of C/EBPα might contribute to its oncogenic function in tumor progression. In conclusion, C/EBPα acts as an oncogene in CRC and could be a potential biomarker of colon carcinogenesis. |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | C/EBPα |
| colorectal cancer |
| EMT |
| metastasis |
| proliferation |
K10plus-PPN: | 1694473252 |
Verknüpfungen: | → Zeitschrift |
Upregulation of C/EBPα contributes to colorectal cancer growth, metastasis and indicates poor survival outcome / Mi, Lan [VerfasserIn]; August 1, 2018 (Online-Ressource)
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