| |  Online-Ressource |
|---|
| Verfasst von: | Micakovic, Tamara [VerfasserIn]  |
|---|
| | Papagiannarou, Stamatia [VerfasserIn] |
|---|
| | Clark, Euan [VerfasserIn] |
|---|
| | Kuzay, Yalçın [VerfasserIn] |
|---|
| | Abramovic, Katarina [VerfasserIn] |
|---|
| | Peters, Jörg [VerfasserIn] |
|---|
| | Sticht, Carsten [VerfasserIn] |
|---|
| | Volk, Nadine [VerfasserIn] |
|---|
| | Fleming, Thomas [VerfasserIn] |
|---|
| | Nawroth, Peter Paul [VerfasserIn] |
|---|
| | Hammes, Hans-Peter [VerfasserIn] |
|---|
| | Alenina, Natalia [VerfasserIn] |
|---|
| | Gröne, Hermann-Josef [VerfasserIn] |
|---|
| | Hoffmann, Sigrid [VerfasserIn] |
|---|
| Titel: | The angiotensin II type 2 receptors protect renal tubule mitochondria in early stages of diabetes mellitus |
|---|
| Verf.angabe: | Tamara Micakovic, Stamatia Papagiannarou, Euan Clark, Yalcin Kuzay, Katarina Abramovic, Jörg Peters, Carsten Sticht, Nadine Volk, Thomas Fleming, Peter Nawroth, Hans-Peter Hammes, Natalia Alenina, Hermann-Josef Gröne and Sigrid Christa Hoffmann |
|---|
| E-Jahr: | 2018 |
|---|
| Jahr: | 4 September 2018 |
|---|
| Umfang: | 14 S. |
|---|
| Fussnoten: | Gesehen am 14.04.2020 |
|---|
| Titel Quelle: | Enthalten in: Kidney international |
|---|
| Ort Quelle: | New York, NY : Elsevier, 1972 |
|---|
| Jahr Quelle: | 2018 |
|---|
| Band/Heft Quelle: | 94(2018), 5, Seite 937-950 |
|---|
| ISSN Quelle: | 1523-1755 |
|---|
| Abstract: | Diabetic nephropathy correlates more closely to defective mitochondria and increased oxidative stress in the kidney than to hyperglycemia. A key driving factor of diabetic nephropathy is angiotensin II acting via the G-protein-coupled cell membrane type 1 receptor. The present study aimed to investigate the role of the angiotensin II type 2 receptor (AT2R) at the early stages of diabetic nephropathy. Using receptor binding studies and immunohistochemistry we found that the mitochondria in renal tubules contain high-affinity AT2Rs. Increased renal mitochondrial AT2R density by transgenic overexpression was associated with reduced superoxide production of isolated mitochondria from non-diabetic rats. Streptozotocin-induced diabetes (28 days) caused a drop in the ATP/oxygen ratio and an increase in the superoxide production of isolated renal mitochondria from wild-type diabetic rats. This correlated with changes in the renal expression profile and increased tubular epithelial cell proliferation. AT2R overexpression in tubular epithelial cells inhibited all diabetes-induced renal changes including a drop in mitochondrial bioenergetics efficiency, a rise in mitochondrial superoxide production, metabolic reprogramming, and increased proliferation. Thus, AT2Rs translocate to mitochondria and can contribute to reno-protective effects at early stages of diabetes. Hence, targeted AT2R overexpression in renal cells may open new avenues to develop novel types of drugs preventing diabetic nephropathy. |
|---|
| DOI: | doi:10.1016/j.kint.2018.06.006 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.kint.2018.06.006 |
|---|
| | DOI: https://doi.org/10.1016/j.kint.2018.06.006 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Adenosine Triphosphate |
|---|
| | angiotensin |
|---|
| | Animals |
|---|
| | Cell Proliferation |
|---|
| | Diabetes Mellitus, Experimental |
|---|
| | Diabetic Nephropathies |
|---|
| | diabetic nephropathy |
|---|
| | Gene Expression Profiling |
|---|
| | Kidney Tubules |
|---|
| | Male |
|---|
| | mitochondria |
|---|
| | Mitochondria |
|---|
| | oxidative stress |
|---|
| | Rats |
|---|
| | Reactive Oxygen Species |
|---|
| | Receptor, Angiotensin, Type 2 |
|---|
| | Streptozocin |
|---|
| K10plus-PPN: | 1694488640 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
¬The¬ angiotensin II type 2 receptors protect renal tubule mitochondria in early stages of diabetes mellitus / Micakovic, Tamara [VerfasserIn]; 4 September 2018 (Online-Ressource)
